MedKoo Cat#: 574438 | Name: WAY 161503 hydrochloride
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

WAY 161503 hydrochloride is a selective 5-HT2C receptor agonist with antidepressant effects.

Chemical Structure

WAY 161503 hydrochloride
WAY 161503 hydrochloride
CAS#276695-22-8

Theoretical Analysis

MedKoo Cat#: 574438

Name: WAY 161503 hydrochloride

CAS#: 276695-22-8

Chemical Formula: C11H12Cl3N3O

Exact Mass: 307.0046

Molecular Weight: 308.59

Elemental Analysis: C, 42.81; H, 3.92; Cl, 34.46; N, 13.62; O, 5.18

Price and Availability

Size Price Availability Quantity
10mg USD 450.00 2 Weeks
50mg USD 1,350.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
WAY 161503 hydrochloride, WAY 161503 HCl
IUPAC/Chemical Name
8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride
InChi Key
YPNWSZJDAKOUAW-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H11Cl2N3O.ClH/c12-6-3-8-9(4-7(6)13)16-2-1-14-5-10(16)11(17)15-8;/h3-4,10,14H,1-2,5H2,(H,15,17);1H
SMILES Code
O=C1C(CNCC2)N2C3=C(C=C(Cl)C(Cl)=C3)N1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 308.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kim ST, Doukmak EJ, Shanguhyia M, Gray DJ, Steinhardt RC. Photoactivatable Agonist-Antagonist Pair as a Tool for Precise Spatiotemporal Control of Serotonin Receptor 2C Signaling. ACS Chem Neurosci. 2023 Oct 4;14(19):3665-3673. doi: 10.1021/acschemneuro.3c00290. Epub 2023 Sep 18. PMID: 37721710; PMCID: PMC10557072. 2: Jastrzębska J, Frankowska M, Smaga I, Hubalewska-Mazgaj M, Suder A, Pieniążek R, Przegaliński E, Filip M. Evaluation of the 5-HT2C receptor drugs RO 60-0175, WAY 161503 and mirtazepine in a preclinical model of comorbidity of depression and cocaine addiction. Pharmacol Rep. 2023 Feb;75(1):99-118. doi: 10.1007/s43440-022-00428-2. Epub 2022 Nov 14. PMID: 36374478; PMCID: PMC9889480. 3: do Carmo Silva RX, do Nascimento BG, Gomes GCV, da Silva NAH, Pinheiro JS, da Silva Chaves SN, Pimentel AFN, Costa BPD, Herculano AM, Lima-Maximino M, Maximino C. 5-HT2C agonists and antagonists block different components of behavioral responses to potential, distal, and proximal threat in zebrafish. Pharmacol Biochem Behav. 2021 Nov;210:173276. doi: 10.1016/j.pbb.2021.173276. Epub 2021 Sep 20. PMID: 34555392. 4: Pérez-Maceira JJ, Otero-Rodiño C, Mancebo MJ, Soengas JL, Aldegunde M. Food intake inhibition in rainbow trout induced by activation of serotonin 5-HT2C receptors is associated with increases in POMC, CART and CRF mRNA abundance in hypothalamus. J Comp Physiol B. 2016 Apr;186(3):313-21. doi: 10.1007/s00360-016-0961-9. Epub 2016 Jan 29. PMID: 26832922. 5: Canal CE, Booth RG, Morgan D. Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response model. Neuropharmacology. 2013 Jul;70:112-21. doi: 10.1016/j.neuropharm.2013.01.007. Epub 2013 Jan 23. PMID: 23353901; PMCID: PMC3754837. 6: Xie DJ, Uta D, Feng PY, Wakita M, Shin MC, Furue H, Yoshimura M. Identification of 5-HT receptor subtypes enhancing inhibitory transmission in the rat spinal dorsal horn in vitro. Mol Pain. 2012 Aug 20;8:58. doi: 10.1186/1744-8069-8-58. PMID: 22906126; PMCID: PMC3495670. 7: Pérez-Maceira JJ, Mancebo MJ, Aldegunde M. Serotonin-induced brain glycogenolysis in rainbow trout (Oncorhynchus mykiss). J Exp Biol. 2012 Sep 1;215(Pt 17):2969-79. doi: 10.1242/jeb.070649. PMID: 22875766. 8: Hayes DJ, Hoang J, Greenshaw AJ. The role of nucleus accumbens shell GABA receptors on ventral tegmental area intracranial self-stimulation and a potential role for the 5-HT(2C) receptor. J Psychopharmacol. 2011 Dec;25(12):1661-75. doi: 10.1177/0269881110389212. Epub 2010 Dec 17. PMID: 21169393. 9: Rekik M, Lluel P, Palea S. 5-Hydroxytryptamine potentiates neurogenic contractions of rat isolated urinary bladder through both 5-HT(7) and 5-HT(2C) receptors. Eur J Pharmacol. 2011 Jan 10;650(1):403-10. doi: 10.1016/j.ejphar.2010.10.027. Epub 2010 Oct 20. PMID: 20969855. 10: Katsidoni V, Apazoglou K, Panagis G. Role of serotonin 5-HT2A and 5-HT2C receptors on brain stimulation reward and the reward-facilitating effect of cocaine. Psychopharmacology (Berl). 2011 Feb;213(2-3):337-54. doi: 10.1007/s00213-010-1887-7. Epub 2010 Jun 25. PMID: 20577718. 11: Nakai K, Nakae A, Oba S, Mashimo T, Ueda K. 5-HT2C receptor agonists attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain. Eur J Pain. 2010 Nov;14(10):999-1006. doi: 10.1016/j.ejpain.2010.04.008. Epub 2010 May 21. PMID: 20488736. 12: Aira Z, Buesa I, Salgueiro M, Bilbao J, Aguilera L, Zimmermann M, Azkue JJ. Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injury. Neuroscience. 2010 Jul 14;168(3):831-41. doi: 10.1016/j.neuroscience.2010.04.032. Epub 2010 Apr 20. PMID: 20412834. 13: Rowland NE, Fakhar KJ, Robertson KL, Haskell-Luevano C. Effect of serotonergic anorectics on food intake and induction of Fos in brain of mice with disruption of melanocortin 3 and/or 4 receptors. Pharmacol Biochem Behav. 2010 Nov;97(1):107-11. doi: 10.1016/j.pbb.2010.03.008. Epub 2010 Mar 27. PMID: 20347864; PMCID: PMC2907462. 14: Quérée P, Peters S, Sharp T. Further pharmacological characterization of 5-HT(2C) receptor agonist-induced inhibition of 5-HT neuronal activity in the dorsal raphe nucleus in vivo. Br J Pharmacol. 2009 Nov;158(6):1477-85. doi: 10.1111/j.1476-5381.2009.00406.x. Epub 2009 Oct 20. PMID: 19845681; PMCID: PMC2795214. 15: Hayes DJ, Clements R, Greenshaw AJ. Effects of systemic and intra-nucleus accumbens 5-HT2C receptor compounds on ventral tegmental area self-stimulation thresholds in rats. Psychopharmacology (Berl). 2009 Apr;203(3):579-88. doi: 10.1007/s00213-008-1404-4. Epub 2008 Nov 25. PMID: 19031071. 16: Hayes DJ, Mosher TM, Greenshaw AJ. Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats. Behav Brain Res. 2009 Feb 11;197(2):323-30. doi: 10.1016/j.bbr.2008.08.034. Epub 2008 Sep 2. PMID: 18805442. 17: Rowland NE, Crump EM, Nguyen N, Robertson K, Sun Z, Booth RG. Effect of (-)-trans-PAT, a novel 5-HT2C receptor agonist, on intake of palatable food in mice. Pharmacol Biochem Behav. 2008 Nov;91(1):176-80. doi: 10.1016/j.pbb.2008.07.004. Epub 2008 Jul 19. PMID: 18692085; PMCID: PMC3712337. 18: Mbaki Y, Ramage AG. Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat. Br J Pharmacol. 2008 Oct;155(3):343-56. doi: 10.1038/bjp.2008.273. Epub 2008 Jul 7. PMID: 18604238; PMCID: PMC2567885. 19: Egashira N, Koushi E, Mishima K, Iwasaki K, Oishi R, Fujiwara M. 2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Delta9-tetrahydrocannabinol- induced catalepsy-like immobilization in mice. J Pharmacol Sci. 2007 Dec;105(4):361-6. doi: 10.1254/jphs.fp0071247. Epub 2007 Dec 1. PMID: 18057774. 20: Boothman L, Raley J, Denk F, Hirani E, Sharp T. In vivo evidence that 5-HT(2C) receptors inhibit 5-HT neuronal activity via a GABAergic mechanism. Br J Pharmacol. 2006 Dec;149(7):861-9. doi: 10.1038/sj.bjp.0706935. Epub 2006 Oct 16. PMID: 17043669; PMCID: PMC2014685.