MedKoo Cat#: 574423 | Name: TC-I-2000
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC-I 2000 is a TRPM8 channel blocker that inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells

Chemical Structure

TC-I-2000
TC-I-2000
CAS#1159996-20-9

Theoretical Analysis

MedKoo Cat#: 574423

Name: TC-I-2000

CAS#: 1159996-20-9

Chemical Formula: C23H18F4N2O

Exact Mass: 414.1355

Molecular Weight: 414.40

Elemental Analysis: C, 66.66; H, 4.38; F, 18.34; N, 6.76; O, 3.86

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,850.00 2 Weeks
1g USD 4,250.00 2 Weeks
2g USD 5,950.00 2 Weeks
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Related CAS #
159996-20-9
Synonym
TC-I-2000; TC-I2000; TC-I 2000; TCI2000; TCI-2000; TCI 2000; TRPM8-IN-1
IUPAC/Chemical Name
N-(4-Fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-2(1H)-isoquinolinecarboxamide
InChi Key
ADCDUDFEGFKKQH-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H18F4N2O/c24-18-9-11-19(12-10-18)28-22(30)29-14-13-15-3-1-2-4-20(15)21(29)16-5-7-17(8-6-16)23(25,26)27/h1-12,21H,13-14H2,(H,28,30)
SMILES Code
O=C(N1C(C2=CC=C(C(F)(F)F)C=C2)C3=C(C=CC=C3)CC1)NC4=CC=C(F)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 414.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Tamayo et al (2012) Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists. J.Med.Chem. 55 1593 PMID: 22329507