MedKoo Cat#: 574422 | Name: TC-1698 dihydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC-1698 dihydrochloride is a selective nicotinic α7 receptor agonist that also displays weak partial agonist/antagonist activity at β-subunit-containing receptors. TC-1698 dihydrochloride exerts neuroprotective effects via activation of the JAK2/PI-3K cascade, which can be neutralized through activation of the angiotensin II (Ang II)

Chemical Structure

TC-1698 dihydrochloride
TC-1698 dihydrochloride
CAS#787587-06-8

Theoretical Analysis

MedKoo Cat#: 574422

Name: TC-1698 dihydrochloride

CAS#: 787587-06-8

Chemical Formula: C13H20Cl2N2

Exact Mass: 274.1004

Molecular Weight: 275.22

Elemental Analysis: C, 56.73; H, 7.33; Cl, 25.76; N, 10.18

Price and Availability

Size Price Availability Quantity
10mg USD 500.00 2 Weeks
50mg USD 1,350.00 2 Weeks
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Related CAS #
No Data
Synonym
TC-1698 dihydrochloride, TC-1698 2HCl
IUPAC/Chemical Name
2-(3-Pyridinyl)-1-azabicyclo[3.2.2]nonane dihydrochloride
InChi Key
ZQUQBCHNSBJMCG-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H18N2.2ClH/c1-2-12(10-14-7-1)13-4-3-11-5-8-15(13)9-6-11;;/h1-2,7,10-11,13H,3-6,8-9H2;2*1H
SMILES Code
[H]Cl.[H]Cl.N1(CC2)C(C3=CC=CN=C3)CCC2CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 275.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Marrero et al (2004) The neuroprotective effect of 2-(3-Pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel α7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J.Pharmacol.Exp.Ther. 309 16 PMID: 14722323 2. Papke et al (2005) Rhesus monkey α7 nicotinic acetylcholine receptors: comparisons to human α7 receptors expressed in Xenopus oocytes. Eur.J.Pharmacol. 524 11 PMID: 16266703