S-24795 | CAS# 304679-75-2 | Partial agonist of α7 nAChR

MedKoo Cat#: 574419 | Name: S-24795

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

S-24795 is a partial agonist of α7 nAChR that has been shown to improve mnemonic function in aged mice for the treatment of aging-related memory disturbances. S-24795 displays more efficient memory-enhancing effects than memantine in Alzheimer's disease mouse models.

Chemical Structure

S-24795

CAS#304679-75-2

Theoretical Analysis

MedKoo Cat#: 574419

Name: S-24795

CAS#: 304679-75-2

Chemical Formula: C14H13BrINO

Exact Mass: 416.9225

Molecular Weight: 418.07

Elemental Analysis: C, 40.22; H, 3.13; Br, 19.11; I, 30.35; N, 3.35; O, 3.83

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 290.00	2 Weeks

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Related CAS #

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Synonym

S-24795, S24795, S 24795

IUPAC/Chemical Name

2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide

InChi Key

LERUHBBUGAOYOD-UHFFFAOYSA-M

InChi Code

InChI=1S/C14H13BrNO.HI/c1-16-9-3-2-4-13(16)10-14(17)11-5-7-12(15)8-6-11;/h2-9H,10H2,1H3;1H/q+1;/p-1

SMILES Code

C[N+]1=CC=CC=C1CC(C2=CC=C(Br)C=C2)=O.[I-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 418.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Musatov A, Carroll CA, Liu YC, Henderson GI, Weintraub ST, Robinson NC. Identification of bovine heart cytochrome c oxidase subunits modified by the lipid peroxidation product 4-hydroxy-2-nonenal. Biochemistry. 2002 Jun 25;41(25):8212-20. doi: 10.1021/bi025896u. PMID: 12069614. 2: Lopez-Hernandez G, Placzek AN, Thinschmidt JS, Lestage P, Trocme-Thibierge C, Morain P, Papke RL. Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAChR responses of hippocampal interneurons. Neuropharmacology. 2007 Jul;53(1):134-44. doi: 10.1016/j.neuropharm.2007.04.007. Epub 2007 Apr 29. PMID: 17544457. 3: Beracochea D, Boucard A, Trocme-Thibierge C, Morain P. Improvement of contextual memory by S 24795 in aged mice: comparison with memantine. Psychopharmacology (Berl). 2008 Mar;196(4):555-64. doi: 10.1007/s00213-007-0987-5. Epub 2007 Nov 22. PMID: 18034231. 4: Lagostena L, Trocme-Thibierge C, Morain P, Cherubini E. The partial alpha7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology. 2008 Mar;54(4):676-85. doi: 10.1016/j.neuropharm.2007.11.016. Epub 2007 Dec 5. PMID: 18187166. 5: Marighetto A, Valerio S, Desmedt A, Philippin JN, Trocmé-Thibierge C, Morain P. Comparative effects of the alpha7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. Psychopharmacology (Berl). 2008 Apr;197(3):499-508. doi: 10.1007/s00213-007-1063-x. Epub 2008 Feb 12. PMID: 18265960. 6: López-Hernández GY, Thinschmidt JS, Morain P, Trocme-Thibierge C, Kem WR, Soti F, Papke RL. Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795. Neuropharmacology. 2009 Mar;56(4):821-30. doi: 10.1016/j.neuropharm.2009.01.011. PMID: 19705574; PMCID: PMC2775526. 7: Wang HY, Stucky A, Liu J, Shen C, Trocme-Thibierge C, Morain P. Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain. J Neurosci. 2009 Sep 2;29(35):10961-73. doi: 10.1523/JNEUROSCI.6088-08.2009. PMID: 19726654; PMCID: PMC6665534. 8: Wang HY, Bakshi K, Shen C, Frankfurt M, Trocmé-Thibierge C, Morain P. S 24795 limits beta-amyloid-alpha7 nicotinic receptor interaction and reduces Alzheimer's disease-like pathologies. Biol Psychiatry. 2010 Mar 15;67(6):522-30. doi: 10.1016/j.biopsych.2009.09.031. Epub 2009 Nov 22. PMID: 19932469. 9: Papke RL, Trocmé-Thibierge C, Guendisch D, Al Rubaiy SA, Bloom SA. Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists. J Pharmacol Exp Ther. 2011 May;337(2):367-79. doi: 10.1124/jpet.110.177485. Epub 2011 Feb 1. PMID: 21285282; PMCID: PMC3083103. 10: Cecon E, Dam J, Luka M, Gautier C, Chollet AM, Delagrange P, Danober L, Jockers R. Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor. Br J Pharmacol. 2019 Sep;176(18):3475-3488. doi: 10.1111/bph.14688. Epub 2019 May 20. PMID: 30981214; PMCID: PMC6715828. 11: Expression of Concern: Wang et al., "Dissociating β-Amyloid from α7 Nicotinic Acetylcholine Receptor by a Novel Therapeutic Agent, S 24795, Normalizes α7 Nicotinic Acetylcholine and NMDA Receptor Function in Alzheimer's Disease Brain". J Neurosci. 2022 Jan 19;42(3):528. doi: 10.1523/JNEUROSCI.2307-21.2021. Epub 2021 Dec 17. PMID: 34921049; PMCID: PMC8802927.