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MedKoo Cat#: 574412 | Name: SR-10067
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SR-10067 is a selective Rev-Erbα/β agonist that increases wakefulness, reduces REM and slow wave sleep in vivo. It also reduces anxiety-like behavior, is cell permeable, and is brain penetrant.

Chemical Structure

SR-10067
SR-10067
CAS#1380548-02-6

Theoretical Analysis

MedKoo Cat#: 574412

Name: SR-10067

CAS#: 1380548-02-6

Chemical Formula: C31H31NO3

Exact Mass: 465.2304

Molecular Weight: 465.59

Elemental Analysis: C, 79.97; H, 6.71; N, 3.01; O, 10.31

Price and Availability

Size Price Availability Quantity
10mg USD 400.00 2 Weeks
50mg USD 1,200.00 2 Weeks
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Related CAS #
No Data
Synonym
SR-10067, SR10067, SR 10067
IUPAC/Chemical Name
[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
InChi Key
MOPAGKWBFUICQT-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H31NO3/c1-31(2,3)35-27-17-15-26(16-18-27)34-21-25-19-23-10-4-5-11-24(23)20-32(25)30(33)29-14-8-12-22-9-6-7-13-28(22)29/h4-18,25H,19-21H2,1-3H3
SMILES Code
O=C(N1CC2=C(C=CC=C2)CC1COC3=CC=C(OC(C)(C)C)C=C3)C4=C5C=CC=CC5=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
SR10067 has high affinity for Rev-Erbβ and Rev-Erbα with IC50 values of 160 nM and 170 nM, respectively.
In vitro activity:
To be determined
In vivo activity:
To be determined
Solvent mg/mL mM comments
Solubility
DMSO 100.0 214.79
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 465.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
To be determined
In vitro protocol:
To be determined
In vivo protocol:
To be determined
1: Banerjee et al (2014) Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. Nat.Commun. 23 5759 PMID: 25536025 2: Thevis et al (2016) Emerging drugs affecting skeletal muscle function and mitochondrial biogenesis - Potential implications for sports drug testing programs. Rapid Commun. Mass Spectrom 30 635 PMID: 26842585