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MedKoo Cat#: 574409 | Name: SNC-162
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SNC-162 is a selective non-peptide δ-opioid receptor agonist that is centrally active following systemic administration in vivo.

Chemical Structure

SNC-162
SNC-162
CAS#178803-51-5

Theoretical Analysis

MedKoo Cat#: 574409

Name: SNC-162

CAS#: 178803-51-5

Chemical Formula: C27H37N3O

Exact Mass: 419.2937

Molecular Weight: 419.61

Elemental Analysis: C, 77.28; H, 8.89; N, 10.01; O, 3.81

Price and Availability

Size Price Availability Quantity
10mg USD 650.00 2 Weeks
50mg USD 1,750.00 2 Weeks
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Related CAS #
No Data
Synonym
SNC-162, SNC162, SNC 162
IUPAC/Chemical Name
4-((S)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(phenyl)methyl)-N,N-diethylbenzamide
InChi Key
WGIDFDFAOQVAHY-UFPGJGBJSA-N
InChi Code
InChI=1S/C27H37N3O/c1-6-18-29-19-22(5)30(20-21(29)4)26(23-12-10-9-11-13-23)24-14-16-25(17-15-24)27(31)28(7-2)8-3/h6,9-17,21-22,26H,1,7-8,18-20H2,2-5H3/t21-,22+,26+/m1/s1
SMILES Code
[H][C@@](C2=CC=CC=C2)(N3C[C@@H](C)N(CC=C)C[C@@H]3C)C1=CC=C(C(N(CC)CC)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
SNC-162 is a δ-opioid receptor agonist with an IC50 of 0.94 nM.
In vitro activity:
SNC-162 concentration-dependently inhibited I(Ca-L) and I(to) in rat ventricular myocytes via activation of the δ-opioid receptors, potentially being the mechanism of antiarrhythmic effects of activating δ-opioid receptors. SNC-162 significantly inhibited both I(Ca-L) and I(to), with a maximal inhibition rate of (46.13±4.12)% and (36.53±10.57)%, respectively. Reference: Sheng Li Xue Bao. 2008 Feb 25;60(1):38-42. https://pubmed.ncbi.nlm.nih.gov/18288356/
In vivo activity:
This study compared the behavioral effects of three diarylpiperazine δ-opioid agonists (SNC80, SNC86, and SNC162) in Sprague-Dawley rats. Of the three, SNC162 had the least potency and efficacy. Reference: J Pharmacol Exp Ther. 2004 Apr;309(1):173-81. https://pubmed.ncbi.nlm.nih.gov/14722329/
Solvent mg/mL mM comments
Solubility
DMSO 5.0 11.92
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 419.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Lin YY, Wu DM, Liu L, Liu QH, Yan ZY, Wu BW. Activation of δ-opioid receptors inhibits L-type Ca(2+) current and transient outward K(+) current in rat ventricular myocytes. Sheng Li Xue Bao. 2008 Feb 25;60(1):38-42. PMID: 18288356. 2. Banks ML, Folk JE, Rice KC, Negus SS. Selective enhancement of fentanyl-induced antinociception by the delta agonist SNC162 but not by ketamine in rhesus monkeys: Further evidence supportive of delta agonists as candidate adjuncts to mu opioid analgesics. Pharmacol Biochem Behav. 2010 Dec;97(2):205-12. doi: 10.1016/j.pbb.2010.07.019. Epub 2010 Aug 3. PMID: 20678514; PMCID: PMC2967222. 3. Jutkiewicz EM, Eller EB, Folk JE, Rice KC, Traynor JR, Woods JH. Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats. J Pharmacol Exp Ther. 2004 Apr;309(1):173-81. doi: 10.1124/jpet.103.061242. Epub 2004 Jan 13. PMID: 14722329.
In vitro protocol:
1. Lin YY, Wu DM, Liu L, Liu QH, Yan ZY, Wu BW. Activation of δ-opioid receptors inhibits L-type Ca(2+) current and transient outward K(+) current in rat ventricular myocytes. Sheng Li Xue Bao. 2008 Feb 25;60(1):38-42. PMID: 18288356.
In vivo protocol:
1. Banks ML, Folk JE, Rice KC, Negus SS. Selective enhancement of fentanyl-induced antinociception by the delta agonist SNC162 but not by ketamine in rhesus monkeys: Further evidence supportive of delta agonists as candidate adjuncts to mu opioid analgesics. Pharmacol Biochem Behav. 2010 Dec;97(2):205-12. doi: 10.1016/j.pbb.2010.07.019. Epub 2010 Aug 3. PMID: 20678514; PMCID: PMC2967222. 2. Jutkiewicz EM, Eller EB, Folk JE, Rice KC, Traynor JR, Woods JH. Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats. J Pharmacol Exp Ther. 2004 Apr;309(1):173-81. doi: 10.1124/jpet.103.061242. Epub 2004 Jan 13. PMID: 14722329.
1: Calderon et al (1997) Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective δ agonist (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-< J.Med.Chem. 40 695 PMID: 9057856 2: Knapp et al (1996) Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. J.Pharmacol.Exp.Ther. 277 1284 PMID: 8667189 3: Negus et al (1998) Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys. J.Pharmacol.Exp.Ther. 286 362 PMID: 9655881 4: Platt, D. M., & Bano, K. M. (2011). Opioid receptors and the discriminative stimulus effects of ethanol in squirrel monkeys: Mu and delta opioid receptor mechanisms. European journal of pharmacology, 650(1), 233-239. 5: Simpson, G. R. (2001). Assessment of delta opioid agonists BW373U86, SNC80 and SNC162 in the conditioned taste aversion design. American University.

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SNAP 398299

SNAP 398299