SF-11 | CAS# 443292-81-7 | NPY Y2 antagonist

MedKoo Cat#: 574402 | Name: SF-11

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SF-11 is an NPY Y2 antagonist that causes significant lethality in mice, displays antidepressant effects in rats, and is brain penetrant.

Chemical Structure

SF-11

CAS#443292-81-7

Theoretical Analysis

MedKoo Cat#: 574402

Name: SF-11

CAS#: 443292-81-7

Chemical Formula: C27H30N2O2S

Exact Mass: 446.2028

Molecular Weight: 446.61

Elemental Analysis: C, 72.61; H, 6.77; N, 6.27; O, 7.16; S, 7.18

Price and Availability

Size	Price	Availability
5mg	USD 315.00	2 Weeks
10mg	USD 515.00	2 Weeks
25mg	USD 925.00	2 Weeks
50mg	USD 1,410.00	2 Weeks
100mg	USD 2,295.00	2 Weeks

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Related CAS #

No Data

Synonym

SF-11, SF11, SF 11

IUPAC/Chemical Name

N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide

InChi Key

PMEQBGAGFZDWQX-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H30N2O2S/c1-2-31-25-15-13-24(14-16-25)28-26(32)29-19-17-23(18-20-29)27(30,21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-16,23,30H,2,17-20H2,1H3,(H,28,32)

SMILES Code

S=C(N1CCC(C(C2=CC=CC=C2)(O)C3=CC=CC=C3)CC1)NC4=CC=C(OCC)C=C4

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO and ethanol

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

SF-11 is an NPY Y2 antagonist (IC50 = 199 nM).

In vitro activity:

To be determined

In vivo activity:

SF-11 elicited a rapid antidepressant-like response in a rat model of depression, possibly linked to its ability to inhibit glutamatergic neurotransmission. SF-11 produced an antidepressant-like effect after single or three-day administration in rats subjected to astrocyte impairment. SF-11 reversed the L-AAA-induced astrocyte cell death in the medial prefrontal cortex, suggesting it is glioprotective. Reference: Behav Brain Res. 2024 Feb 4;457:114729. https://pubmed.ncbi.nlm.nih.gov/37871655/

	Solvent	mg/mL	mM
Solubility
	DMSO	44.7	100.00
	Ethanol	22.3	50.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 446.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Domin H, Konieczny J, Cieślik P, Pochwat B, Wyska E, Szafarz M, Lenda T, Biała D, Gąsior Ł, Śmiałowska M, Szewczyk B. The antidepressant-like and glioprotective effects of the Y2 receptor antagonist SF-11 in the astroglial degeneration model of depression in rats: Involvement of glutamatergic inhibition. Behav Brain Res. 2024 Feb 4;457:114729. doi: 10.1016/j.bbr.2023.114729. Epub 2023 Oct 21. PMID: 37871655. 2. Domin H, Piergies N, Pięta E, Wyska E, Pochwat B, Wlaź P, Śmiałowska M, Paluszkiewicz C, Szewczyk B. Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11. ACS Chem Neurosci. 2019 Aug 21;10(8):3454-3463. doi: 10.1021/acschemneuro.9b00082. Epub 2019 Jul 3. PMID: 31267743.

In vitro protocol:

To be determined

In vivo protocol:

1: Zhang R, Yin Y, Zhang Y, Feng Y, Meng H, Wang J, Zhang M, Zhang J. Physical activity, weight management, and mental health during COVID-19 lockdown: A cross-sectional study of healthcare students in China. PLoS One. 2024 Oct 17;19(10):e0302894. doi: 10.1371/journal.pone.0302894. PMID: 39418249; PMCID: PMC11486394. 2: Göldel JM, Warschburger P. Validation of a German version of the caregiver strain questionnaire-short form 11 (CGSQ-SF11). BMC Psychol. 2024 Jul 10;12(1):386. doi: 10.1186/s40359-024-01875-7. PMID: 38987850; PMCID: PMC11234714. 3: Singhal S, Wang Y, Qin Z, Peterson DR, Dunne RF, Culakova E, Hopkins JO, Melnyk N, Onitilo A, Targia V, Mohile S, Loh KP. Nutritional impairment, psychological health and quality of life among older adults with advanced cancer: A secondary analysis of a randomized clinical trial. Cancer Med. 2024 Jun;13(12):e7348. doi: 10.1002/cam4.7348. PMID: 38898664; PMCID: PMC11187162. 4: Sobrini-Morillo P, Ravot C, Herlédan C, Sánchez-Castellano C, Cruz-Jentoft AJ, Falandry C. Real-world experience with CDK4-6 inhibition in the old and oldest old with a diagnosis of breast cancer. Semin Oncol. 2024 Jun- Aug;51(3-4):95-105. doi: 10.1053/j.seminoncol.2024.01.003. Epub 2024 Feb 22. PMID: 38604898. 5: Ercan N, Arıcan G, Şibar K, Özmeriç A, İltar S. Clinical and Functional Outcomes of Suture Versus Headless Screw Fixation for Tibial Eminence Fractures in Children. Am J Sports Med. 2024 Mar;52(4):948-955. doi: 10.1177/03635465241227440. Epub 2024 Feb 22. PMID: 38385198. 6: Wambogo EA, Ansai N, Herrick KA, Reedy J, Hales CM, Ogden CL. Differences in Intakes of Select Nutrients by Urbanization Level in the United States Population 2 Years and Older, NHANES 2013-2018. J Nutr. 2024 Feb;154(2):617-625. doi: 10.1016/j.tjnut.2023.12.030. Epub 2023 Dec 22. PMID: 38142922; PMCID: PMC10900191. 7: Domin H, Konieczny J, Cieślik P, Pochwat B, Wyska E, Szafarz M, Lenda T, Biała D, Gąsior Ł, Śmiałowska M, Szewczyk B. The antidepressant-like and glioprotective effects of the Y2 receptor antagonist SF-11 in the astroglial degeneration model of depression in rats: Involvement of glutamatergic inhibition. Behav Brain Res. 2024 Feb 4;457:114729. doi: 10.1016/j.bbr.2023.114729. Epub 2023 Oct 21. PMID: 37871655. 8: Choi JH, Lee YS, Hwang KT, Jo YH, Shin HS, Kim J, Park KC. Usefulness of a drill stopper to prevent iatrogenic soft tissue injury in orthopedic surgery. Heliyon. 2023 Oct 7;9(10):e20772. doi: 10.1016/j.heliyon.2023.e20772. PMID: 37860561; PMCID: PMC10582358. 9: Sanchez-Rodriguez D, Demonceau C, Bruyère O, Cavalier E, Reginster JY, Beaudart C. Intrinsic capacity and risk of death: Focus on the impact of using different diagnostic criteria for the nutritional domain. Maturitas. 2023 Oct;176:107817. doi: 10.1016/j.maturitas.2023.107817. Epub 2023 Aug 3. PMID: 37573805. 10: Maurya P, Verma R. MIP integrated surface plasmon resonance in vitro detection of sodium benzoate. Analyst. 2023 Feb 27;148(5):1141-1150. doi: 10.1039/d2an01910h. PMID: 36728403. 11: Zhang L, Zhang X, Liang Z. Post-Harvest Processing Methods Have Critical Roles in the Contents of Active Ingredients of Scutellaria baicalensis Georgi. Molecules. 2022 Nov 28;27(23):8302. doi: 10.3390/molecules27238302. PMID: 36500395; PMCID: PMC9739255. 12: Tian L, Wang L, Zhang X, Huang X, Wang F, Zhu S, Li X, Guan Y. Multi-omics analysis on seasonal variations of the biofilm microbial community in a full- scale pre-denitrification biofilter. Environ Sci Pollut Res Int. 2023 Feb;30(9):24284-24298. doi: 10.1007/s11356-022-23539-y. Epub 2022 Nov 5. PMID: 36334202. 13: Zhang L, Zhang X, Begum N, Xia P, Liu J, Liang Z. Effects of Different Processing Methods Based on Different Drying Conditions on the Active Ingredients of Salvia miltiorrhiza Bunge. Molecules. 2022 Jul 29;27(15):4860. doi: 10.3390/molecules27154860. PMID: 35956808; PMCID: PMC9369592. 14: Zora S, Custodero C, Pers YM, Valsecchi V, Cella A, Ferri A, Pisano-González MM, Peñacoba Maestre D, Vazquez Alvarez R, Raat H, Baker G, Pilotto A. Impact of the chronic disease self-management program (CDSMP) on self-perceived frailty condition: the EU-EFFICHRONIC project. Ther Adv Chronic Dis. 2021 Nov 20;12:20406223211056722. doi: 10.1177/20406223211056722. PMID: 34820081; PMCID: PMC8606718. 15: Genest F, Rak D, Bätz E, Ott K, Seefried L. Sarcopenia and Malnutrition Screening in Female Osteoporosis Patients-A Cross-Sectional Study. J Clin Med. 2021 May 27;10(11):2344. doi: 10.3390/jcm10112344. PMID: 34071858; PMCID: PMC8198508. 16: Li X, Liu J, Chang Q, Zhou Z, Han R, Liang Z. Antioxidant and Antidiabetic Activity of Proanthocyanidins from Fagopyrum dibotrys. Molecules. 2021 Apr 21;26(9):2417. doi: 10.3390/molecules26092417. PMID: 33919259; PMCID: PMC8122523. 17: Elbatran AI, Li A, Gallagher MM, Kaba R, Norman M, Behr ER, Sohal M, Bajpai A, Zuberi Z, Saba MM. Contact force sensing in ablation of ventricular arrhythmias using a 56-hole open-irrigation catheter: a propensity-matched analysis. J Interv Card Electrophysiol. 2021 Apr;60(3):543-553. doi: 10.1007/s10840-020-00756-4. Epub 2020 May 21. PMID: 32440943; PMCID: PMC8134314. 18: Erring M, Gaba S, Mohsina S, Tripathy S, Sharma RK. Comparison of efficacy of silver-nanoparticle gel, nano-silver-foam and collagen dressings in treatment of partial thickness burn wounds. Burns. 2019 Dec;45(8):1888-1894. doi: 10.1016/j.burns.2019.07.019. Epub 2019 Aug 2. PMID: 31383609. 19: Domin H, Piergies N, Pięta E, Wyska E, Pochwat B, Wlaź P, Śmiałowska M, Paluszkiewicz C, Szewczyk B. Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11. ACS Chem Neurosci. 2019 Aug 21;10(8):3454-3463. doi: 10.1021/acschemneuro.9b00082. Epub 2019 Jul 3. PMID: 31267743. 20: Jiang H, Li XM, Li MT, Zheng XC, Liu HJ, Zhang Y, Ge HY. [3D electronic anatomy mapping guided radiofrequency catheter ablation in 95 children with atrioventricular nodal reentrant tachycardia]. Zhonghua Er Ke Za Zhi. 2018 Sep 2;56(9):674-679. Chinese. doi: 10.3760/cma.j.issn.0578-1310.2018.09.008. PMID: 30180406.