Synonym
A6770, A 6770, A-6770
IUPAC/Chemical Name
1-(5-(hydroxymethyl)-1H-imidazol-2-yl)ethan-1-one
InChi Key
JXDVIQLWMKAZBS-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H8N2O2/c1-4(10)6-7-2-5(3-9)8-6/h2,9H,3H2,1H3,(H,7,8)
SMILES Code
CC(C1=NC=C(CO)N1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
140.14
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ohtoyo M, Machinaga N, Inoue R, Hagihara K, Yuita H, Tamura M, Hashimoto R, Chiba J, Muro F, Watanabe J, Kobayashi Y, Abe K, Kita Y, Nagasaki M, Shimozato T. Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. Cell Chem Biol. 2016 May 19;23(5):555-560. doi: 10.1016/j.chembiol.2016.04.007. Epub 2016 May 12. PMID: 27185637.
2: van Roeden SE, Belle-van Meerkerk G, van Tuyl SA, van de Ree MA, Muller AF. Domperidon en het risico op acute hartdood [Domperidone and the risk of sudden cardiac death]. Ned Tijdschr Geneeskd. 2013;157(45):A6770. Dutch. PMID: 24191928.
3: Kaliszczak M, Antonow D, Patel KI, Howard P, Jodrell DI, Thurston DE, Guichard SM. Optimization of the antitumor activity of sequence-specific pyrrolobenzodiazepine derivatives based on their affinity for ABC transporters. AAPS J. 2010 Dec;12(4):617-27. doi: 10.1208/s12248-010-9225-x. Epub 2010 Aug 12. PMID: 20703960; PMCID: PMC2977001.
