IUPAC/Chemical Name
4-Amino-N-(5-chloro-2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide
InChi Key
JQBLWVSZNZIWFC-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H13ClN4O2S/c1-7-11(13)12(16-8(2)15-7)17-20(18,19)10-5-3-9(14)4-6-10/h3-6H,14H2,1-2H3,(H,15,16,17)
SMILES Code
O=S(C1=CC=C(N)C=C1)(NC2=NC(C)=NC(C)=C2Cl)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
312.77
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Peiker G, Traeger A, Nöschel H, Bonow A, Hertel U. Untersuchungen zur Kinetik von Sulfaclomid und der Einfluss der Sulfaclomidtherapie auf die p-Aminohippursäure-Clearance in der Schwángerschaft [Studies on the kinetics of sulfaclomide and the effect of sulfaclomide therapy on p-aminohippuric acid clearance in pregnancy]. Zentralbl Gynakol. 1975;97(10):612-8. German. PMID: 1189751.
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5: Bräunlich H, Splinter FK. Zur Pharmakokinetik von Sulfamerazin, Sulfamethoxypyridazin und Sulfaclomid bei jungen und erwachsenen Ratten [Pharmacokinetics of sulfamerazine, sulfamethoxypyridazine and sulfaclomide in young and adult rats]. Acta Biol Med Ger. 1974;32(2-3):235-47. German. PMID: 4423849.
6: Fleck C, Nguyen Trong T, Bräunlich H. Relation between renal and hepatic excretion of drugs. XII. Influence of dexamethasone, triiodothyronine, or phenobarbital on the elimination of sulfonamides in rats of different ages. Exp Pathol. 1989;36(1):43-52. PMID: 2731589.
7: Seidel K. Therapie des rheumatischen Fiebers [Therapy of rheumatic fever]. Z Gesamte Inn Med. 1977 Jul 15;32(14):347-51. German. PMID: 335683.
8: Knoll U, Kühnert M, Walther H. Untersuchungen zum Einfluss von Huminsäuren auf die Resorption von Sulfaclomid bei Laboratoriumsratten [Effect of humic acids on the resorption of sulfaclomide in laboratory rats]. Arch Exp Veterinarmed. 1985 May;39(3):350-4. German. PMID: 2932083.
9: Heise GW, Paul G. Klinische Untersuchungen mit dem Langzeitsulfonamid Sulfaclomid [Clinical studies with a delayed-action sulfonamide, Sulfaclomide]. Z Urol Nephrol. 1969;62(4):303-6. German. PMID: 5403763.
10: Bräunlich H, Splinter FK. Renale Ausscheidung von Langzeitsulfonamiden bei Flüssigkeitsbelastung und Anderung des pH-Wertes des Harns [Renal excretion of long term sulfonamides under fluid administration and modification of the urinary pH value]. Acta Biol Med Ger. 1976;35(6):793-8. German. PMID: 10708.
11: Storch R, Brünlich H. Stimulierung der renalen Ausscheidung von- Aminohippursäure durch wiederholte Zufuhr von Pharmaka bei jungen und erwachsenen Ratten [Stimulation of renal excretion of p-aminohippuric acid by repeated administration of drugs in young and adult rats]. Acta Biol Med Ger. 1975;34(9):1529-39. German. PMID: 1221741.
