Synonym
PNU-22394 hydrochloride, PNU-22394 HCl
IUPAC/Chemical Name
6-Methyl-1,2,3,4,5,6-hexahydro-azepino[4,5-b]indole hydrochloride
InChi Key
SAIGGEUWSYESTR-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H16N2.ClH/c1-15-12-5-3-2-4-10(12)11-6-8-14-9-7-13(11)15;/h2-5,14H,6-9H2,1H3;1H
SMILES Code
CN1C(CCNCC2)=C2C3=C1C=CC=C3.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
PNU-22394 hydrochloride is an agonist at 5-HT2C receptors and partial agonist at 5-HT2A and 5-HT2B receptors.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
236.74
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Dunlop, j. et al. WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity. J. Pharmacol. Exp. Ther. 2005, 313(2), 862-869.
2. Bishop, M.J. et al. New 5-HT2C receptor agonists Expert Opin. Ther. Patents 2003, 13 (11), 1691-1705.
3. RB McCall et al. PNU-22394, a 5-HT2C receptor agonist, reduces feeding in rodents and produces weight loss in humans. Neuroscience 2001 Abstract, Presentation Number: 309.2
