MS-245 oxalate | CAS# 275363-58-1 | 5-HT6 antagonist

MedKoo Cat#: 574379 | Name: MS-245 oxalate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MS-245 oxalate is a high affinity 5-HT6 antagonist that potentiates the hypolocomotor actions of (-)-nicotine in mice.

Chemical Structure

MS-245 oxalate

CAS#275363-58-1

Theoretical Analysis

MedKoo Cat#: 574379

Name: MS-245 oxalate

CAS#: 275363-58-1

Chemical Formula: C21H24N2O7S

Exact Mass: 448.1304

Molecular Weight: 448.49

Elemental Analysis: C, 56.24; H, 5.39; N, 6.25; O, 24.97; S, 7.15

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 395.00	2 Weeks
50mg	USD 855.00	2 Weeks

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Related CAS #

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Synonym

MS-245 oxalate, MS 245 oxalate, MS245 oxalate

IUPAC/Chemical Name

5-Methoxy-N,N-dimethyl-1-(phenylsulfonyl)-1H-indole-3-ethanamine oxalate

InChi Key

BLSWAEGCRSFTJG-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H22N2O3S.C2H2O4/c1-20(2)12-11-15-14-21(19-10-9-16(24-3)13-18(15)19)25(22,23)17-7-5-4-6-8-17;3-1(4)2(5)6/h4-10,13-14H,11-12H2,1-3H3;(H,3,4)(H,5,6)

SMILES Code

O=S(N1C=C(CCN(C)C)C2=C1C=CC(OC)=C2)(C3=CC=CC=C3)=O.O=C(O)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

MS 245 oxalate is a potent antagonist of 5-HT6 receptor with a Ki of 2 nM.

In vitro activity:

TBD

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 448.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1. Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164 2. Dukat et al (2008) Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. J.Med.Chem. 51 603 PMID: 18201064 3. Nirogi et al (2010) Novel and potent 5-piperazinyl methyl-N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands. ACS Med.Chem.Lett. 1 340 4. Young et al (2006) Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (-)nicotine. Pharmacol.Biochem.Behav. 85 170 PMID: 16950502