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MedKoo Cat#: 574378 | Name: MRT-10
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MRT-10 is a Smoothened (Smo) receptor antagonist that inhibits ShhN-induced Gli luciferase reporter activity in Shh-light 2 cells and acts as an inverse agonist during nontranscriptional Hedgehog pathway activation.

Chemical Structure

MRT-10
MRT-10
CAS#330829-30-6

Theoretical Analysis

MedKoo Cat#: 574378

Name: MRT-10

CAS#: 330829-30-6

Chemical Formula: C24H23N3O5S

Exact Mass: 465.1358

Molecular Weight: 465.52

Elemental Analysis: C, 61.92; H, 4.98; N, 9.03; O, 17.18; S, 6.89

Price and Availability

Size Price Availability Quantity
5mg USD 255.00 2 Weeks
10mg USD 415.00 2 Weeks
25mg USD 710.00 2 Weeks
50mg USD 1,045.00 2 Weeks
100mg USD 1,565.00 2 Weeks
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Related CAS #
No Data
Synonym
MRT 10, MRT-10, MRT10
IUPAC/Chemical Name
N-((3-benzamidophenyl)carbamothioyl)-3,4,5-trimethoxybenzamide
InChi Key
KVQVEZQDNHMQJV-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H23N3O5S/c1-30-19-12-16(13-20(31-2)21(19)32-3)23(29)27-24(33)26-18-11-7-10-17(14-18)25-22(28)15-8-5-4-6-9-15/h4-14H,1-3H3,(H,25,28)(H2,26,27,29,33)
SMILES Code
O=C(NC(NC2=CC(NC(C3=CC=CC=C3)=O)=CC=C2)=S)C1=CC(OC)=C(OC)C(OC)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
MRT-10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 75.3 161.82
DMSO:PBS (pH 7.2) (1:1) 0.3 0.64
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 465.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1. Solinas et al (2012) Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J.Med.Chem. 55 1559 PMID: 22268551 2. Manetti et al (2010) Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol.Pharmacol. 78 658 PMID: 20664000