JW-67 is a Wnt pathway inhibitor that targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. JW-67 is selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κB pathways. It blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines.
MedKoo Cat#: 574368
Name: JW-67
CAS#: 442644-28-2
Chemical Formula: C21H18N2O6
Exact Mass: 394.1165
Molecular Weight: 394.38
Elemental Analysis: C, 63.96; H, 4.60; N, 7.10; O, 24.34
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.7 | 113.39 |
The following data is based on the product molecular weight 394.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
