MedKoo Cat#: 574360 | Name: FR-171113
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

FR-171113 is a protease-activated receptor 1 (PAR1) antagonist. FR-171113 exhibits potent anti-platelet activity in vitro and inhibits thrombin TRAP-6-induced platelet aggregation with no effect on coagulation time.

Chemical Structure

FR-171113
FR-171113
CAS#173904-50-2

Theoretical Analysis

MedKoo Cat#: 574360

Name: FR-171113

CAS#: 173904-50-2

Chemical Formula: C19H11Cl3N2O4S

Exact Mass: 467.9505

Molecular Weight: 469.72

Elemental Analysis: C, 48.58; H, 2.36; Cl, 22.64; N, 5.96; O, 13.62; S, 6.83

Price and Availability

Size Price Availability Quantity
10mg USD 600.00 2 Weeks
50mg USD 1,500.00 2 Weeks
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Related CAS #
No Data
Synonym
FR 171113, FR-171113, FR171113
IUPAC/Chemical Name
methyl (2E)-2-[3-(4-chlorophenyl)-2-(2,4-dichlorobenzoyl)imino-4-oxo-1,3-thiazolidin-5-ylidene]acetate
InChi Key
SDGLYCKTPKZBGI-FIJPKLNTSA-N
InChi Code
InChI=1S/C19H11Cl3N2O4S/c1-28-16(25)9-15-18(27)24(12-5-2-10(20)3-6-12)19(29-15)23-17(26)13-7-4-11(21)8-14(13)22/h2-9H,1H3/b15-9-,23-19-
SMILES Code
COC(=O)/C=C/1\C(=O)N(C(=NC(=O)C2=C(C=C(C=C2)Cl)Cl)S1)C3=CC=C(C=C3)Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 469.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Kato et al (1999) In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist. Eur.J.Pharmacol. 384 197 PMID: 10611442 Kato et al (2003) Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig. Eur.J.Pharmacol. 473 163 PMID: 12892834