MedKoo Cat#: 574352 | Name: DMAB-anabaseine dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DMAB-anabaseine dihydrochloride is a partial agonist at α7-containing neuronal nicotinic receptors (nAChR) and antagonist at α4β2 and other nicotinic receptors. DMAB-anabaseine 2HCl displays specific cognition-enhancing effects and improves long-term memory in rats.

Chemical Structure

DMAB-anabaseine dihydrochloride
DMAB-anabaseine dihydrochloride
CAS# 154149-38-9

Theoretical Analysis

MedKoo Cat#: 574352

Name: DMAB-anabaseine dihydrochloride

CAS#: 154149-38-9

Chemical Formula: C19H23Cl2N3

Exact Mass:

Molecular Weight: 364.31

Elemental Analysis: C, 62.64; H, 6.36; Cl, 19.46; N, 11.53

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Related CAS #
32013-69-7 (free base)
Synonym
DMAB-anabaseine dihydrochloride, DMAB-anabaseine 2HCl
IUPAC/Chemical Name
4-[(5,6-Dihydro[2,3'-bipyridin]-3(4H)-ylidene)methyl]-N,N-dimethylbenzenamine dihydrochloride
InChi Key
DHCNEWWWKHBASC-YNHPUKFJSA-N
InChi Code
InChI=1S/C19H21N3.2ClH/c1-22(2)18-9-7-15(8-10-18)13-16-5-4-12-21-19(16)17-6-3-11-20-14-17;;/h3,6-11,13-14H,4-5,12H2,1-2H3;2*1H/b16-13+;;
SMILES Code
CN(C)C1=CC=C(/C=C2/C(C3=CN=CC=C3)=NCCC2)C=C1.Cl.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
DMAB-anabaseine dihydrochloride is a partial agonist at α7-containing neuronal nicotinic receptors (nAChR) and antagonist at α4β2 and other nicotinic receptors.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 364.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1. Arendash et al (1995) Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res. 674 252 PMID: 7796104 2. Kem et al (1997) Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 283 979 PMID: 9399967 3. Stevens et al (1998) Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology 136 320 PMID: 9600576