BA-1 | CAS# 183241-31-8 | Bombesin receptor agonist

MedKoo Cat#: 574337 | Name: BA-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BA-1 is a potent bombesin receptor agonist that enhances glucose transport in obese and diabetic primary myocytes. BA-1 also stimulates NCI-H1299 lung cancer cell proliferation in vitro.

Chemical Structure

BA-1

CAS#183241-31-8

Theoretical Analysis

MedKoo Cat#: 574337

Name: BA-1

CAS#: 183241-31-8

Chemical Formula: C57H76N14O11

Exact Mass: 1132.5818

Molecular Weight: 1133.32

Elemental Analysis: C, 60.41; H, 6.76; N, 17.30; O, 15.53

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Synonym

BA 1, BA-1, BA1

IUPAC/Chemical Name

(S)-N1-((2S,5S,8S,11S,14S,17S,20S)-14-((1H-imidazol-4-yl)methyl)-17-benzyl-20-carbamoyl-1-(1H-indol-3-yl)-8-isopropyl-5,11-dimethyl-3,6,9,12,15,18-hexaoxo-4,7,10,13,16,19-hexaazatetracosan-2-yl)-2-((R)-2-amino-3-(4-hydroxyphenyl)propanamido)pentanediamide

InChi Key

BXSSCSKCOFKPOK-ZWAOGYCRSA-N

InChi Code

InChI=1S/C57H76N14O11/c1-6-7-16-42(49(60)74)66-55(80)44(25-34-13-9-8-10-14-34)69-56(81)46(27-37-29-61-30-63-37)68-50(75)32(4)65-57(82)48(31(2)3)71-51(76)33(5)64-54(79)45(26-36-28-62-41-17-12-11-15-39(36)41)70-53(78)43(22-23-47(59)73)67-52(77)40(58)24-35-18-20-38(72)21-19-35/h8-15,17-21,28-33,40,42-46,48,62,72H,6-7,16,22-27,58H2,1-5H3,(H2,59,73)(H2,60,74)(H,61,63)(H,64,79)(H,65,82)(H,66,80)(H,67,77)(H,68,75)(H,69,81)(H,70,78)(H,71,76)/t32-,33-,40+,42-,43-,44-,45-,46-,48-/m0/s1

SMILES Code

[H]N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCC)C(N)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,133.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

González et al (2015) Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes Int.J.Mol.Med. 35 925 PMID: 25653074 Moody et al (2015) ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Peptides 64 55 PMID: 25554218 Moreno et al (2013) Comparative pharmacology of bombesin receptor subtype-3, nonpeptide agonist MK-5046, a universal peptide agonist, and peptide antagonist Bantag-1 for human bombesin receptors. J.Pharmacol.Exp.Ther. 347 100 PMID: 23892571 Mantey et al (1997) Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors. J Biol Chem. 272 26062 PMID: 9325344