Ginsenoside CK is a metabolite of the saponin ginsenoside Rb1 formed from ginsenoside Rb1 via intestinal bacterial exo-β-D-glucosidase. It reduces protein levels of matrix metalloproteinase-2 (MMP-2) and pro-MMP-9 in, and inhibits growth, adhesion, and invasion of, MHCC97-H human hepatocellular carcinoma cells (HCCs). It inhibits metastasis in an MHCC97-H mouse xenograft model but does not reduce tumor growth. Ginsenoside CK reduces the percentage of memory B cells in the spleen, the number of swollen joints, and lymph node hyperplasia in an adjuvant-induced model of rheumatoid arthritis. It increases the activity of pSer9-glycogen synthase kinase and insulin degrading enzyme (IDE) and reduces the accumulation of amyloid-β (1-42) (Aβ42) in the rat hippocampal CA1 and CA3 regions in a model of vascular dementia induced by chronic cerebral hypofusion. It also increases the percentage of time spent in the target quadrant of the Morris water maze when administered at doses of 100 and 200 mg/kg in the same model.
MedKoo Cat#: 574324
Name: Ginsenoside CK
CAS#: 39262-14-1
Chemical Formula: C36H62O8
Exact Mass: 622.4445
Molecular Weight: 622.88
Elemental Analysis: C, 69.42; H, 10.03; O, 20.55
The following data is based on the product molecular weight 622.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
