p-Hydroxyhippuric acid | CAS# 2482-25-9 | OAT1 inhibitor

MedKoo Cat#: 574323 | Name: p-Hydroxyhippuric acid

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

p-Hydroxyhippuric acid is a dihydroxy phenolic acid inhibitor of organic anion transporter 1 (OAT1). It increases the production of free radicals and reduces the secretion of TNF-α, but not IL-1β or IL-6, in isolated human peripheral blood mononuclear cells (PBMCs) stimulated with LPS.

Chemical Structure

p-Hydroxyhippuric acid

CAS#2482-25-9

Theoretical Analysis

MedKoo Cat#: 574323

Name: p-Hydroxyhippuric acid

CAS#: 2482-25-9

Chemical Formula: C9H9NO4

Exact Mass: 195.0532

Molecular Weight: 195.17

Elemental Analysis: C, 55.39; H, 4.65; N, 7.18; O, 32.79

Price and Availability

Size	Price	Availability
100mg	USD 210.00	2 Weeks
250mg	USD 350.00	2 Weeks
500mg	USD 545.00	2 Weeks
1g	USD 775.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

p-Hydroxyhippuric acid, 4-Hydroxyhippuric Acid, para-Hydroxyhippuric Acid

IUPAC/Chemical Name

N-(4-hydroxybenzoyl)-glycine

InChi Key

ZMHLUFWWWPBTIU-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H9NO4/c11-7-3-1-6(2-4-7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)

SMILES Code

OC1=CC=C(C(NCC(O)=O)=O)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

4-Hydroxyhippuric acid is a by-product of metabolism of polyphenols and increases the microflora activity related to the refeeding.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	1.0	5.12
	DMF:PBS (pH 7.2) (1:10)	0.1	0.46
	DMSO	100.0	512.36

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 195.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Wang F, Zhong ZR, Xie Q, Ou J, Xiong NX, Huang MZ, Li SY, Hu G, Qin ZL, Luo SW. Multiomics Analyses Explore the Immunometabolic Interplay in the Liver of White Crucian Carp (Carassius cuvieri) After Aeromonas veronii Challenge. Mar Biotechnol (NY). 2024 Aug;26(4):790-809. doi: 10.1007/s10126-024-10347-3. Epub 2024 Jul 23. PMID: 39042324. 2: Isaiah S, Loots DT, van Furth AMT, Davoren E, van Elsland S, Solomons R, van der Kuip M, Mason S. Urinary markers of Mycobacterium tuberculosis and dysbiosis in paediatric tuberculous meningitis cases undergoing treatment. Gut Pathog. 2024 Mar 12;16(1):14. doi: 10.1186/s13099-024-00609-9. PMID: 38475868; PMCID: PMC10936073. 3: Jayakrishnan T, Mariam A, Farha N, Rotroff DM, Aucejo F, Barot SV, Conces M, Nair KG, Krishnamurthi SS, Schmit SL, Liska D, Khorana AA, Kamath SD. Plasma metabolomic differences in early-onset compared to average-onset colorectal cancer. Sci Rep. 2024 Feb 21;14(1):4294. doi: 10.1038/s41598-024-54560-5. PMID: 38383634; PMCID: PMC10881959. 4: Wang S, Fang J, Li J, Wang S, Su P, Wan Y, Tao F, Sun Y. Identification of urine biomarkers associated with early puberty in children: An untargeted metabolomics analysis. Physiol Behav. 2023 Oct 15;270:114305. doi: 10.1016/j.physbeh.2023.114305. Epub 2023 Jul 27. PMID: 37507079. 5: Folz JS, Shalon D, Fiehn O. Metabolomics analysis of time-series human small intestine lumen samples collected in vivo. Food Funct. 2021 Oct 4;12(19):9405-9415. doi: 10.1039/d1fo01574e. PMID: 34606553. 6: Senta I, Rodríguez-Mozaz S, Corominas L, Petrovic M. Wastewater-based epidemiology to assess human exposure to personal care and household products - A review of biomarkers, analytical methods, and applications. Trends Environ Anal Chem. 2020 Dec;28:e00103. doi: 10.1016/j.teac.2020.e00103. Epub 2020 Sep 3. PMID: 38620429; PMCID: PMC7470864. 7: Araújo BR, Furtado DZS, de Moura Leite FBV, de Assunção NA, Carrilho E. Metabolic profiling of organic acids in urine samples of Cri Du Chat syndrome individuals by gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Sep 15;1153:122267. doi: 10.1016/j.jchromb.2020.122267. Epub 2020 Jul 14. PMID: 32739788. 8: Wang Z, Jiang H, Chen X, Song X, Xu F, Chen F, Mao Z, Gao S, Chen W. A rapid and sensitive method for simultaneous determination of eight protein-bound uremic toxins in human serum by UHPLC-MS/MS: application in assessing peritoneal dialysis. J Pharm Biomed Anal. 2020 Jul 15;186:113312. doi: 10.1016/j.jpba.2020.113312. Epub 2020 Apr 17. PMID: 32361090. 9: Pimenta do Nascimento T, Barros Santos MC, Pimentel de Abreu J, Lengruber Gonçalves Teixeira de Almeida I, Barreto da Silva Feijó M, Junger Teodoro A, Simões Larraz Ferreira M, Cameron LC, Bello Koblitz MG. Effects of cooking on the phytochemical profile of breadfruit as revealed by high-resolution UPLC- MSE. J Sci Food Agric. 2020 Mar 30;100(5):1962-1970. doi: 10.1002/jsfa.10209. Epub 2020 Jan 16. PMID: 31846074. 10: Shin MY, Shin C, Choi JW, Lee J, Lee S, Kim S. Pharmacokinetic profile of propyl paraben in humans after oral administration. Environ Int. 2019 Sep;130:104917. doi: 10.1016/j.envint.2019.104917. Epub 2019 Jun 21. PMID: 31234001. 11: Zhang L, Zou W, Huang Y, Wen X, Huang J, Wang Y, Sheng X. A Preliminary Study of Uric Metabolomic Alteration for Postpartum Depression Based on Liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry. Dis Markers. 2019 Apr 24;2019:4264803. doi: 10.1155/2019/4264803. PMID: 31178941; PMCID: PMC6507152. 12: Nowak PJ, Wilk R, Prymont-Przyminska A, Zwolinska A, Sarniak A, Wlodarczyk A, de Graft-Johnson J, Mamelka B, Zasowska-Nowak A, Bartnicki P, Nowak D, Nowicki M. Hemodialysis Decreases the Concentration of Accumulated Plant Phenols in the Plasma of Patients on Maintenance Dialysis: Influence of Residual Renal Function. Ther Apher Dial. 2017 Dec;21(6):572-585. doi: 10.1111/1744-9987.12586. Epub 2017 Oct 11. PMID: 29024501. 13: Muhrez K, Largeau B, Emond P, Montigny F, Halimi JM, Trouillas P, Barin-Le Guellec C. Single nucleotide polymorphisms of ABCC2 modulate renal secretion of endogenous organic anions. Biochem Pharmacol. 2017 Sep 15;140:124-138. doi: 10.1016/j.bcp.2017.05.012. Epub 2017 May 19. PMID: 28532626. 14: Prymont-Przyminska A, Bialasiewicz P, Zwolinska A, Sarniak A, Wlodarczyk A, Markowski J, Rutkowski KP, Nowak D. Addition of strawberries to the usual diet increases postprandial but not fasting non-urate plasma antioxidant activity in healthy subjects. J Clin Biochem Nutr. 2016 Nov;59(3):191-198. doi: 10.3164/jcbn.15-113. Epub 2016 Aug 19. PMID: 27895386; PMCID: PMC5110932. 15: Aschoff JK, Riedl KM, Cooperstone JL, Högel J, Bosy-Westphal A, Schwartz SJ, Carle R, Schweiggert RM. Urinary excretion of Citrus flavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study. Mol Nutr Food Res. 2016 Dec;60(12):2602-2610. doi: 10.1002/mnfr.201600315. Epub 2016 Sep 12. PMID: 27488098; PMCID: PMC7301357. 16: Moos RK, Angerer J, Dierkes G, Brüning T, Koch HM. Metabolism and elimination of methyl, iso- and n-butyl paraben in human urine after single oral dosage. Arch Toxicol. 2016 Nov;90(11):2699-2709. doi: 10.1007/s00204-015-1636-0. Epub 2015 Nov 25. PMID: 26608183. 17: Ludwig IA, Mena P, Calani L, Borges G, Pereira-Caro G, Bresciani L, Del Rio D, Lean ME, Crozier A. New insights into the bioavailability of red raspberry anthocyanins and ellagitannins. Free Radic Biol Med. 2015 Dec;89:758-69. doi: 10.1016/j.freeradbiomed.2015.10.400. Epub 2015 Oct 22. PMID: 26475039. 18: Orrego-Lagarón N, Martínez-Huélamo M, Vallverdú-Queralt A, Lamuela-Raventos RM, Escribano-Ferrer E. High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism. Br J Nutr. 2015 Jul;114(2):169-80. doi: 10.1017/S0007114515001671. Epub 2015 Jun 17. PMID: 26083965. 19: Das MK, Bishwal SC, Das A, Dabral D, Badireddy VK, Pandit B, Varghese GM, Nanda RK. Deregulated tyrosine-phenylalanine metabolism in pulmonary tuberculosis patients. J Proteome Res. 2015 Apr 3;14(4):1947-56. doi: 10.1021/acs.jproteome.5b00016. Epub 2015 Mar 2. PMID: 25693719. 20: Pereira-Caro G, Borges G, van der Hooft J, Clifford MN, Del Rio D, Lean ME, Roberts SA, Kellerhals MB, Crozier A. Orange juice (poly)phenols are highly bioavailable in humans. Am J Clin Nutr. 2014 Nov;100(5):1378-84. doi: 10.3945/ajcn.114.090282. Epub 2014 Aug 27. PMID: 25332336.