MedKoo Cat#: 462157 | Name: UK 370106
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

UK-370106 is a selective inhibitor of mitochondrial complex I, which is part of the electron transport chain responsible for ATP production in mitochondria. By targeting this enzyme, UK-370106 disrupts the normal function of oxidative phosphorylation, leading to reduced ATP synthesis and potentially causing mitochondrial dysfunction. This compound has been investigated for its potential use in treating diseases associated with mitochondrial dysfunction, such as neurodegenerative diseases and metabolic disorders.

Chemical Structure

UK 370106
UK 370106
CAS#230961-21-4

Theoretical Analysis

MedKoo Cat#: 462157

Name: UK 370106

CAS#: 230961-21-4

Chemical Formula: C35H44N2O5

Exact Mass: 572.3250

Molecular Weight: 572.75

Elemental Analysis: C, 73.40; H, 7.74; N, 4.89; O, 13.97

Price and Availability

Size Price Availability Quantity
10mg USD 600.00 2 Weeks
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Related CAS #
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Synonym
UK 370106; UK-370106; UK370106
IUPAC/Chemical Name
(R)-3-(((S)-1-(((S)-2-methoxy-1-phenylethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)-6-(2-methyl-[1,1'-biphenyl]-4-yl)hexanoic acid
InChi Key
NSMABJUGSNPHMN-BHYWQNONSA-N
InChi Code
InChI=1S/C35H44N2O5/c1-24-21-25(19-20-29(24)26-14-8-6-9-15-26)13-12-18-28(22-31(38)39)33(40)37-32(35(2,3)4)34(41)36-30(23-42-5)27-16-10-7-11-17-27/h6-11,14-17,19-21,28,30,32H,12-13,18,22-23H2,1-5H3,(H,36,41)(H,37,40)(H,38,39)/t28-,30-,32-/m1/s1
SMILES Code
O=C([C@H](CCCC1=CC=C(C2=CC=CC=C2)C(C)=C1)CC(O)=O)N[C@@H](C(C)(C)C)C(N[C@H](COC)C3=CC=CC=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 572.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Howe, N., Ceruso, M., Spink, E., & Malthouse, J. P. G. (2011). pH stability of the stromelysin-1 catalytic domain and its mechanism of interaction with a glyoxal inhibitor. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1814(10), 1394-1403. Whitlock, G. A., Dack, K. N., Dickinson, R. P., & Lewis, M. L. (2007). A novel series of highly selective inhibitors of MMP-3. Bioorganic & medicinal chemistry letters, 17(24), 6750-6753. Ashcroft, C. P., Challenger, S., Derrick, A. M., Storey, R., & Thomson, N. M. (2003). Asymmetric synthesis of an MMP-3 inhibitor incorporating a 2-alkyl succinate motif. Organic process research & development, 7(3), 362-368. Matthews, K. H., Stevens, H. N. E., Auffret, A. D., Humphrey, M. J., & Eccleston, G. M. (2008). Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. International journal of pharmaceutics, 356(1-2), 110-120. Taylor, L. J., Papadopoulos, D. G., Dunn, P. J., Bentham, A. C., Mitchell, J. C., & Snowden, M. J. (2004). Mechanical characterisation of powders using nanoindentation. Powder Technology, 143, 179-185.