MS 347a | CAS#144678-18-2 | MLCK Inhibitor

MedKoo Cat#: 534797 | Name: MS 347a

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MS 347a is a myosin light chain kinase (MLCK) inhibitor; an epoxide analog of sydowinin B (MS-347b).

Chemical Structure

MS 347a

CAS#144678-18-2

Theoretical Analysis

MedKoo Cat#: 534797

Name: MS 347a

CAS#: 144678-18-2

Chemical Formula: C16H12O7

Exact Mass: 316.0583

Molecular Weight: 316.27

Elemental Analysis: C, 60.76; H, 3.82; O, 35.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

MS 347a; MS-347a; MS347a

IUPAC/Chemical Name

9bH-Oxireno(a)xanthene-9b-carboxylic acid, 1a,9-dihydro-8-hydroxy-6-(hydroxymethyl)-9-oxo-, methyl ester

InChi Key

DYSASOJNGXSFHH-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H12O7/c1-21-15(20)16-11(23-16)3-2-9-13(16)14(19)12-8(18)4-7(6-17)5-10(12)22-9/h2-5,11,17-18H,6H2,1H3

SMILES Code

O=C(C12C(C3=O)=C(OC4=C3C(O)=CC(CO)=C4)C=CC1O2)OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 316.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nakanishi S, Ando K, Kawamoto I, Matsuda Y. MS-347a, a new inhibitor of myosin light chain kinase from Aspergillus sp. KY52178. J Antibiot (Tokyo). 1993 Dec;46(12):1775-81. doi: 10.7164/antibiotics.46.1775. Erratum in: J Antibiot (Tokyo) 1994 Apr;47(4):C-2. PMID: 8294233. 2: Rao K, Paik WY, Zheng L, Jobin RM, Tomić M, Jiang H, Nakanishi S, Stojilkovic SS. Wortmannin-sensitive and -insensitive steps in calcium-controlled exocytosis in pituitary gonadotrophs: evidence that myosin light chain kinase mediates calcium-dependent and wortmannin-sensitive gonadotropin secretion. Endocrinology. 1997 Apr;138(4):1440-9. doi: 10.1210/endo.138.4.5078. PMID: 9075700. 3: Nakanishi S, Catt KJ, Balla T. Inhibition of agonist-stimulated inositol 1,4,5-trisphosphate production and calcium signaling by the myosin light chain kinase inhibitor, wortmannin. J Biol Chem. 1994 Mar 4;269(9):6528-35. PMID: 8120005.