CAY10749 is a dual inhibitor of poly(ADP-ribose) polymerase (PARP) and PI3K. It is selective for these enzymes over PI3Kβ and PI3Kγ as well as a panel of 374 additional kinases at 1 µM. CAY10749 (1 µM) induces dsDNA break formation in a neutral comet assay and apoptosis in MDA-MB-468 breast cancer cells. It inhibits proliferation of eight cancer cell lines, including pancreatic, ovarian, lymphoma, leukemia, and lung cancer cells.
MedKoo Cat#: 462132
Name: CAY10749
CAS#: 2337386-47-5
Chemical Formula: C33H28F4N8O3
Exact Mass: 660.2220
Molecular Weight: 660.63
Elemental Analysis: C, 60.00; H, 4.27; F, 11.50; N, 16.96; O, 7.27
The following data is based on the product molecular weight 660.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
