Hydroxychlorodenafil is a synthetic PDE5 inhibitor structurally related to sildenafil, designed to enhance cGMP-mediated vasodilation in smooth muscle tissues. It works by inhibiting phosphodiesterase type 5, thereby increasing intracellular cGMP levels, leading to relaxation of vascular smooth muscle, particularly in the corpus cavernosum. While not approved for therapeutic use, hydroxychlorodenafil has been identified as an undeclared adulterant in some illicit or counterfeit sexual enhancement products and studied for its potential oncological applications due to PDE pathway modulation.
MedKoo Cat#: 462118
Name: Hydroxychlorodenafil
CAS#: 1391054-00-4
Chemical Formula: C19H23ClN4O3
Exact Mass: 390.1459
Molecular Weight: 390.87
Elemental Analysis: C, 58.39; H, 5.93; Cl, 9.07; N, 14.33; O, 12.28
The following data is based on the product molecular weight 390.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
