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MedKoo Cat#: 462112 | Name: Excisanin A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Excisanin A is a diterpenoid compound purified from Isodon macrocalyxin D that has anti-cancer properties with little toxicity.

Chemical Structure

Excisanin A
Excisanin A
CAS#78536-37-5

Theoretical Analysis

MedKoo Cat#: 462112

Name: Excisanin A

CAS#: 78536-37-5

Chemical Formula: C20H30O5

Exact Mass: 350.2093

Molecular Weight: 350.46

Elemental Analysis: C, 68.55; H, 8.63; O, 22.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Excisanin A
IUPAC/Chemical Name
Kaur-16-en-15-one, 1,7,12,14-tetrahydroxy-, (1alpha,7alpha,12alpha,14R)-
InChi Key
NFENNPKUXFGPST-WEMBNSTNSA-N
InChi Code
InChI=1S/C20H30O5/c1-9-15-10(21)7-12-19(4)11(18(2,3)6-5-13(19)22)8-14(23)20(12,16(9)24)17(15)25/h10-15,17,21-23,25H,1,5-8H2,2-4H3/t10-,11+,12-,13-,14+,15+,17+,19+,20-/m0/s1
SMILES Code
C=C([C@H]([C@@H](O)C1)[C@H]2O)C([C@@]32[C@H](O)C[C@]4([H])C(C)(C)CC[C@H](O)[C@@]4(C)[C@@]31[H])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 350.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Qin J, Tang J, Jiao L, et al. A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin β1/FAK/PI3K/AKT/β-catenin signaling. Life Sci. 2013;93(18-19):655‐663. doi:10.1016/j.lfs.2013.09.002. 2:Zhang XY, Wu XQ, Deng R, Sun T, Feng GK, Zhu XF. Upregulation of sestrin 2 expression via JNK pathway activation contributes to autophagy induction in cancer cells. Cell Signal. 2013;25(1):150‐158. doi:10.1016/j.cellsig.2012.09.004. 3: Deng R, Li W, Guan Z, et al. Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis. Oncogene. 2006;25(53):7070‐7077. doi:10.1038/sj.onc.1209686. 4: Deng R, Tang J, Xia LP, et al. ExcisaninA, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway. Mol Cancer Ther. 2009;8(4):873‐882. doi:10.1158/1535-7163.MCT-08-1080. 5: Jin RL, Cheng PY, Xu GY. Yao Xue Xue Bao. 1985;20(5):366‐371.