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MedKoo Cat#: 462113 | Name: KAT-681 free acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KAT-681 free acid is a liver-selective thyromimetic.

Chemical Structure

KAT-681 free acid
KAT-681 free acid
CAS#364332-60-5

Theoretical Analysis

MedKoo Cat#: 462113

Name: KAT-681 free acid

CAS#: 364332-60-5

Chemical Formula: C24H22FNO6

Exact Mass: 439.1431

Molecular Weight: 439.44

Elemental Analysis: C, 65.60; H, 5.05; F, 4.32; N, 3.19; O, 21.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
KAT-681 free acid
IUPAC/Chemical Name
Propanoic acid, 3-((4-(3-((4-fluorophenyl)hydroxymethyl)-4-hydroxyphenoxy)-3,5-dimethylphenyl)amino)-3-oxo-
InChi Key
GHKUCWZCPWQVQJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H22FNO6/c1-13-9-17(26-21(28)12-22(29)30)10-14(2)24(13)32-18-7-8-20(27)19(11-18)23(31)15-3-5-16(25)6-4-15/h3-11,23,27,31H,12H2,1-2H3,(H,26,28)(H,29,30)
SMILES Code
O=C(O)CC(NC1=CC(C)=C(OC2=CC=C(O)C(C(C3=CC=C(F)C=C3)O)=C2)C(C)=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 439.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: The Liver-Selective Thyromimetic T-0681 Influences Reverse Cholesterol Transport and Atherosclerosis Development in Mice Ivan Tancevski, Egon Demetz, Philipp Eller, Kristina Duwensee, Julia Hoefer, Christiane Heim, Ursula Stanzl, Andreas Wehinger, Kristina Auer, Regina Karer, Julia Huber, Wilfried Schgoer, Miranda Van Eck, Jonathan Vanhoutte, Catherine Fievet, Frans Stellaard, Mats Rudling, Josef R. Patsch, Andreas Ritsch PLoS One. 2010; 5(1): e8722. Published online 2010 Jan 15. doi: 10.1371/journal.pone.0008722 PMCID: PMC2806908 2: The resurgence of thyromimetics as lipid-modifying agents I Tancevski, P Eller, JR Patsch, A Ritsch Curr Opin Investig Drugs. Author manuscript; available in PMC 2010 Nov 29.Published in final edited form as: Curr Opin Investig Drugs. 2009 Sep; 10(9): 912–918. PMCID: PMC2993058 3: THYROID HORMONE ANALOGUES FOR THE TREATMENT OF METABOLIC DISORDERS: NEW POTENTIAL FOR UNMET CLINICAL NEEDS? Timothy J. Shoemaker, Tatsuyoshi Kono, Cary N. Mariash, Carmella Evans-Molina Endocr Pract. Author manuscript; available in PMC 2013 Nov 1.Published in final edited form as: Endocr Pract. 2012 Nov-Dec; 18(6): 954–964. doi: 10.4158/EP12086.RA PMCID: PMC3745011 4: Potential role of two novel agonists of thyroid hormone receptor‐β on liver regeneration Andrea Perra, Marta Anna Kowalik, Lavinia Cabras, Massimiliano Runfola, Simona Sestito, Cristina Migliore, Silvia Giordano, Grazia Chiellini, Simona Rapposelli, Amedeo Columbano Cell Prolif. 2020 May; 53(5): e12808. Published online 2020 Apr 29. doi: 10.1111/cpr.12808 PMCID: PMC7260063 5: The thyromimetic T-0681 protects from atherosclerosis Ivan Tancevski, Andreas Wehinger, Egon Demetz, Julia Hoefer, Philipp Eller, Eva Huber, Ursula Stanzl, Kristina Duwensee, Kristina Auer, Wilfried Schgoer, Volker Kuhn, Catherine Fievet, Frans Stellaard, Mats Rudling, Bernhard Foeger, Josef R. Patsch, Andreas Ritsch J Lipid Res. 2009 May; 50(5): 938–944. doi: 10.1194/jlr.M800553-JLR200 PMCID: PMC2666180.

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GW-870086

GW-870086

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