IUPAC/Chemical Name
(E)-2-(5-(4-methylpiperazin-1-yl)-9H-dithieno[3,4-b:3',4'-e]azepin-9-ylidene)acetonitrile
InChi Key
RVQVUMIXBGFJLZ-SWGQDTFXSA-N
InChi Code
InChI=1S/C17H16N4S2/c1-20-4-6-21(7-5-20)17-15-10-22-8-13(15)12(2-3-18)14-9-23-11-16(14)19-17/h2,8-11H,4-7H2,1H3/b12-2+
SMILES Code
CN1CCN(C2=NC3=CSC=C3/C(C4=CSC=C42)=C/C#N)CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
340.46
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Pharmacological Analysis of the Novel, Rapid, and Potent Inactivation of the Human 5-Hydroxytryptamine7 Receptor by Risperidone, 9-OH-Risperidone, and Other Inactivating Antagonists Jessica A. Knight, Carol Smith, Nicole Toohey, Michael T. Klein, Milt Teitler Mol Pharmacol. 2009 Feb; 75(2): 374–380. Published online 2008 Nov 7. doi: 10.1124/mol.108.052084 PMCID: PMC2671286
2: Antipsychotics for treatment of delirium in hospitalised non‐ICU patients Lisa Burry, Sangeeta Mehta, Marc M Perreault, Jay S Luxenberg, Najma Siddiqi, Brian Hutton, Dean A Fergusson, Chaim Bell, Louise Rose Cochrane Database Syst Rev. 2018 Jun; 2018(6): CD005594. Published online 2018 Jun 18. doi: 10.1002/14651858.CD005594.pub3 PMCID: PMC6513380
3: Human 5-HT7 Receptor-Induced Inactivation of Forskolin-Stimulated Adenylate Cyclase by Risperidone, 9-OH-Risperidone and Other “Inactivating Antagonists” Nicole Toohey, Michael T. Klein, Jessica Knight, Carol Smith, Milt Teitler Mol Pharmacol. 2009 Sep; 76(3): 552–559. Published online 2009 Jun 9. doi: 10.1124/mol.109.056283 PMCID: PMC2730387
4: Role of Serotonin in Central Dopamine Dysfunction Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo CNS Neurosci Ther. 2010 Jun; 16(3): 179–194. Published online 2010 May 6. doi: 10.1111/j.1755-5949.2010.00135.x PMCID: PMC6493878
