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MedKoo Cat#: 534650 | Name: Moxaverine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Moxaverine is a peripheral nervous system agent.

Chemical Structure

Moxaverine
Moxaverine
CAS#10539-19-2

Theoretical Analysis

MedKoo Cat#: 534650

Name: Moxaverine

CAS#: 10539-19-2

Chemical Formula: C20H21NO2

Exact Mass: 307.1572

Molecular Weight: 307.39

Elemental Analysis: C, 78.15; H, 6.89; N, 4.56; O, 10.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Moxaverine
IUPAC/Chemical Name
1-Benzyl-3-ethyl-6,7-dimethoxyisoquinoline
InChi Key
MYCMTMIGRXJNSO-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H21NO2/c1-4-16-11-15-12-19(22-2)20(23-3)13-17(15)18(21-16)10-14-8-6-5-7-9-14/h5-9,11-13H,4,10H2,1-3H3
SMILES Code
COC1=CC2=C(C=C1OC)C=C(CC)N=C2CC3=CC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 307.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
This message contains search results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM). Do not reply directly to this message Sent On: Fri May 29 09:19:14 2020 10 selected items PubMed Results Items 1-10 of 10 (Display the 10 citations in PubMed) 1: Schmidl D, Pemp B, Lasta M, Boltz A, Kaya S, Palkovits S, Prager F, Schmetterer L, Garhofer G. Effects of orally administered moxaverine on ocular blood flow in healthy subjects. Graefes Arch Clin Exp Ophthalmol. 2013 Feb;251(2):515-20. doi: 10.1007/s00417-012-2207-1. Epub 2012 Dec 1. PMID: 23203292. 2: Resch H, Weigert G, Karl K, Pemp B, Garhofer G, Schmetterer L. Effect of systemic moxaverine on ocular blood flow in humans. Acta Ophthalmol. 2009 Nov;87(7):731-5. doi: 10.1111/j.1755-3768.2008.01338.x. Epub 2008 Sep 5. PMID: 18778333. 3: Leung E, Landa G. Update on current and future novel therapies for dry age- related macular degeneration. Expert Rev Clin Pharmacol. 2013 Sep;6(5):565-79. doi: 10.1586/17512433.2013.829645. Epub 2013 Aug 24. PMID: 23971874. 4: Pemp B, Garhofer G, Lasta M, Schmidl D, Wolzt M, Schmetterer L. The effects of moxaverine on ocular blood flow in patients with age-related macular degeneration or primary open angle glaucoma and in healthy control subjects. Acta Ophthalmol. 2012 Mar;90(2):139-45. doi: 10.1111/j.1755-3768.2010.01878.x. Epub 2010 Apr 23. PMID: 20456253. 5: Becker U, Ehrhardt C, Schaefer UF, Gukasyan HJ, Kim KJ, Lee VH, Lehr CM. Tissue distribution of moxaverine-hydrochloride in the rabbit eye and plasma. J Ocul Pharmacol Ther. 2005 Jun;21(3):210-6. doi: 10.1089/jop.2005.21.210. PMID: 15969638. 6: Mannhold R. Inhibition of calmodulin dependent c-AMP-phosphodiesterase by moxaverine and papaverine. Arzneimittelforschung. 1988 Dec;38(12):1806-8. PMID: 2854468. 7: Schmid-Schönbein H, Schröder S, Grebe R, Artmann G, Eschweiler H, Teitel P. Influence of moxaverine hydrochloride on membrane curvature and microsieve filterability of red cells after exposure to hyperosmolarity and lactacidosis. Arzneimittelforschung. 1988 May;38(5):710-6. PMID: 3415714. 8: Chen R, Qi J, Mao Z, Cui S. Rh(iii)-catalyzed C-H activation/cyclization of oximes with alkenes for regioselective synthesis of isoquinolines. Org Biomol Chem. 2016 Jul 14;14(26):6201-4. doi: 10.1039/c6ob00942e. Epub 2016 Jun 8. PMID: 27273816. 9: Lu Q, Greßies S, Cembellín S, Klauck FJR, Daniliuc CG, Glorius F. Redox- Neutral Manganese(I)-Catalyzed C-H Activation: Traceless Directing Group Enabled Regioselective Annulation. Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12778-12782. doi: 10.1002/anie.201707396. Epub 2017 Sep 5. PMID: 28809458. 10: Becker U, Ehrhardt C, Schneider M, Muys L, Gross D, Eschmann K, Schaefer UF, Lehr CM. A comparative evaluation of corneal epithelial cell cultures for assessing ocular permeability. Altern Lab Anim. 2008 Feb;36(1):33-44. doi: 10.1177/026119290803600106. PMID: 18333713.

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