IUPAC/Chemical Name
2,3-Dihydro-1-(methoxymethyl)-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-on
InChi Key
CWCAUFWLFIUQHP-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H15N3O4/c1-24-11-19-15-8-7-13(20(22)23)9-14(15)17(18-10-16(19)21)12-5-3-2-4-6-12/h2-9H,10-11H2,1H3
SMILES Code
O=C1N(COC)C2=CC=C([N+]([O-])=O)C=C2C(C3=CC=CC=C3)=NC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
325.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Nikoui V, Ostadhadi S, Azhand P, Zolfaghari S, Amiri S, Foroohandeh M, Motevalian M, Sharifi AM, Bakhtiarian A. The effect of nitrazepam on depression and curiosity in behavioral tests in mice: The role of potassium channels. Eur J Pharmacol. 2016 Nov 15;791:369-376. doi: 10.1016/j.ejphar.2016.09.017. Epub 2016 Sep 9. PMID: 27615446.
2: Konishi K, Fukami T, Gotoh S, Nakajima M. Identification of enzymes responsible for nitrazepam metabolism and toxicity in human. Biochem Pharmacol. 2017 Sep 15;140:150-160. doi: 10.1016/j.bcp.2017.06.114. Epub 2017 Jun 10. PMID: 28606603.
3: Girwood RH. Nitrazepam nightmares. Br Med J. 1973 Feb 10;1(5849):353. doi: 10.1136/bmj.1.5849.353. PMID: 4685632; PMCID: PMC1588181.
4: Yasuda K. [Benzodiazepine (clonazepam, nitrazepam, diazepam)]. Nihon Rinsho. 2004 Dec;62 Suppl 12:360-3. Japanese. PMID: 15658338.
5: Luurila H, Olkkola KT, Neuvonen PJ. Interaction between erythromycin and nitrazepam in healthy volunteers. Pharmacol Toxicol. 1995 Apr;76(4):255-8. doi: 10.1111/j.1600-0773.1995.tb00139.x. PMID: 7617555.
6: Kangas L, Breimer DD. Clinical pharmacokinetics of nitrazepam. Clin Pharmacokinet. 1981 Sep-Oct;6(5):346-66. doi: 10.2165/00003088-198106050-00002. PMID: 7037262.
7: Rosen GM, Rauckman EJ, Wilson RL Jr, Tschanz C. Production of superoxide during the metabolism of nitrazepam. Xenobiotica. 1984 Oct;14(10):785-94. doi: 10.3109/00498258409151477. PMID: 6095542.
8: Lim HC, Nigro MA, Beierwaltes P, Tolia V, Wishnow R. Nitrazepam-induced cricopharyngeal dysphagia, abnormal esophageal peristalsis and associated bronchospasm: probable cause of nitrazepam-related sudden death. Brain Dev. 1992 Sep;14(5):309-14. doi: 10.1016/s0387-7604(12)80149-5. PMID: 1456385.
9: Hosain SA, Green NS, Solomon GE, Chutorian A. Nitrazepam for the treatment of Lennox-Gastaut syndrome. Pediatr Neurol. 2003 Jan;28(1):16-9. doi: 10.1016/s0887-8994(02)00461-7. PMID: 12657414.
10: Moriya F, Hashimoto Y. Tissue distribution of nitrazepam and 7-aminonitrazepam in a case of nitrazepam intoxication. Forensic Sci Int. 2003 Jan 28;131(2-3):108-12. doi: 10.1016/s0379-0738(02)00421-8. PMID: 12590048.