H3B-616 is potent allosteric inhibitor of CPS1 (IC50 = 66 nM). Carbamoyl phosphate synthetase 1 (CPS1) is a potential synthetic lethal target in LKB1-deficient nonsmall cell lung cancer, where its overexpression supports the production of pyrimidine synthesis.
MedKoo Cat#: 462071
Name: H3B-616
CAS#: 2468199-06-4
Chemical Formula: C23H24FN3O3
Exact Mass: 409.1802
Molecular Weight: 409.46
Elemental Analysis: C, 67.47; H, 5.91; F, 4.64; N, 10.26; O, 11.72
The following data is based on the product molecular weight 409.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
