JT86 is a highly potent HDAC inhibitor with IC50 0.7 nM. JT86 is an achiral AR-42 analogues incorporating a cycloalkyl group linked via a quaternary carbon atom, with up to 40-fold increased potency against human class I HDACs, 25-fold increased cytotoxicity against five human cancer cell lines, and up to 70-fold less toxicity in normal human cells. JT86 was ninefold more potent than racAR-42 inpromoting accumulation of acetylated histone H4 in MM96L melanoma cells.
MedKoo Cat#: 462069
Name: JT86
CAS#: unknown
Chemical Formula: C23H22N2O4
Exact Mass: 390.1580
Molecular Weight: 390.44
Elemental Analysis: C, 70.75; H, 5.68; N, 7.18; O, 16.39
The following data is based on the product molecular weight 390.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
