MedKoo Cat#: 462062 | Name: GGTI-2734

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GGTI-2734 is a farnesyl and geranylgeranyl transferase inhibitor that thwarts mutant KRAS-driven patient-derived pancreatic tumors.

Chemical Structure

GGTI-2734
GGTI-2734
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 462062

Name: GGTI-2734

CAS#: unknown

Chemical Formula: C23H31N5O4

Exact Mass: 441.2376

Molecular Weight: 441.53

Elemental Analysis: C, 62.57; H, 7.08; N, 15.86; O, 14.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GGTI-2734; GGTI2734; GGTI 2734
IUPAC/Chemical Name
((S)-2-benzyl-4-((4-methyl-1H-imidazol-5-yl)methyl)-3-oxopiperazine-1-carbonyl)-L-leucine
InChi Key
COLCNDRDBCLVOC-ICSRJNTNSA-N
InChi Code
InChI=1S/C23H31N5O4/c1-15(2)11-18(22(30)31)26-23(32)28-10-9-27(13-19-16(3)24-14-25-19)21(29)20(28)12-17-7-5-4-6-8-17/h4-8,14-15,18,20H,9-13H2,1-3H3,(H,24,25)(H,26,32)(H,30,31)/t18-,20-/m0/s1
SMILES Code
O=C1[C@H](CC2=CC=CC=C2)N(C(N[C@@H](CC(C)C)C(O)=O)=O)CCN1CC3=C(C)N=CN3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 441.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dual farnesyl and geranylgeranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang, Liwei Chen, Perry Kennedy, Ayaz Mohamed, Steven Fletcher, Christopher Cummings, Harshani Lawrence, Francisca Beato, Ya’an Kang, Michael P. Kim, Andrea Delitto, Patrick Underwood, Jason B. Fleming, Jose Trevino, Andrew D. Hamilton, Said M. Sebti Clin Cancer Res. Author manuscript; available in PMC 2019 Oct 2.Published in final edited form as: Clin Cancer Res. 2019 Oct 1; 25(19): 5984–5996. Published online 2019 Jun 21. doi: 10.1158/1078-0432.CCR-18-3399 PMCID: PMC6774803