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MedKoo Cat#: 555792 | Name: TLR4-C34
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TLR4-C34 is a TLR4 inhibitor that inhibits TLR4 signaling in enterocytes and macrophages in vitro when used at 10 µM.

Chemical Structure

TLR4-C34
TLR4-C34
CAS#40592-88-9

Theoretical Analysis

MedKoo Cat#: 555792

Name: TLR4-C34

CAS#: 40592-88-9

Chemical Formula: C17H27NO9

Exact Mass: 389.1686

Molecular Weight: 389.40

Elemental Analysis: C, 52.44; H, 6.99; N, 3.60; O, 36.98

Price and Availability

Size Price Availability Quantity
50mg USD 650.00 2 Weeks
100mg USD 1,050.00 2 Weeks
200mg USD 1,650.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,650.00 2 Weeks
2g USD 5,650.00 2 Weeks
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Related CAS #
No Data
Synonym
TLR4-C34; TLR4-C-34; TLR4-C 34; C34; C 34; C-34; TLR4-IN-C34; Toll-Like Receptor 4-C34;
IUPAC/Chemical Name
(2R,3S,4R,5R,6S)-5-acetamido-2-(acetoxymethyl)-6-isopropoxytetrahydro-2H-pyran-3,4-diyl diacetate
InChi Key
KMIQMFHPUJUDMC-HHARLNAUSA-N
InChi Code
InChI=1S/C17H27NO9/c1-8(2)24-17-14(18-9(3)19)16(26-12(6)22)15(25-11(5)21)13(27-17)7-23-10(4)20/h8,13-17H,7H2,1-6H3,(H,18,19)/t13-,14-,15-,16-,17+/m1/s1
SMILES Code
CC(O[C@H]1O[C@@H]([C@H]([C@@H]([C@H]1NC(C)=O)OC(C)=O)OC(C)=O)COC(C)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 38.9 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 389.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Abdelsalam HM, Helal MG, Abu-Elsaad NM. TLR4-IN-C34 protects against acute kidney injury via modulating TLR4/MyD88/NF-κb axis, MAPK, and apoptosis. Iran J Basic Med Sci. 2022 Nov;25(11):1334-1340. doi: 10.22038/IJBMS.2022.67168.14727. PMID: 36474570; PMCID: PMC9699956. 2: Zhang SS, Liu M, Liu DN, Yang YL, Du GH, Wang YH. TLR4-IN-C34 Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses via Downregulating TLR4/MyD88/NF-κB/NLRP3 Signaling Pathway and Reducing ROS Generation in BV2 Cells. Inflammation. 2022 Apr;45(2):838-850. doi: 10.1007/s10753-021-01588-8. Epub 2021 Nov 2. PMID: 34727285. 3: Chen Y, Li D, Sun L, Qi K, Shi L. Pharmacological inhibition of toll-like receptor 4 with TLR4-IN-C34 modulates the intestinal flora homeostasis and the MyD88/NF-κB axis in ulcerative colitis. Eur J Pharmacol. 2022 Nov 5;934:175294. doi: 10.1016/j.ejphar.2022.175294. Epub 2022 Sep 21. PMID: 36152840. 4: Adegoke EO, Adeniran SO, Zeng Y, Wang X, Wang H, Wang C, Zhang H, Zheng P, Zhang G. Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells. J Appl Toxicol. 2019 Jun;39(6):832-843. doi: 10.1002/jat.3771. Epub 2019 Jan 22. PMID: 30671980. 5: Cheng Y, Li C, Chen Y, Liu H, Wan H, Kang X, Guo S. Water pollutant cadmium- induced intestinal inflammation in Eriocheir sinensis and potential therapeutic drugs. Sci Total Environ. 2024 Dec 10;955:177132. doi: 10.1016/j.scitotenv.2024.177132. Epub 2024 Oct 21. PMID: 39442721. 6: Sivak KV, Stosman KI, Rassokha TA, Aleksandrov AG, Kuzmich NN, Orshanskaya YR, Savateeva-Lubimova TN, Lesiovskaya EE. The Effect of TLR4 Blockade on Some Indicators of Systemic Inflammatory Response to Proteus mirabilis LPS in Rats. Bull Exp Biol Med. 2020 Oct;169(6):795-797. doi: 10.1007/s10517-020-04981-9. Epub 2020 Oct 24. PMID: 33098506. 7: Karunarathne WAHM, Molagoda IMN, Choi YH, Park SR, Lee S, Kim GY. Bisphenol A: A potential Toll-like receptor 4/myeloid differentiation factor 2 complex agonist. Environ Pollut. 2021 Jun 1;278:116829. doi: 10.1016/j.envpol.2021.116829. Epub 2021 Mar 1. PMID: 33706241. 8: Lee TH, Park D, Kim YJ, Lee I, Kim S, Oh CT, Kim JY, Yang J, Jo SK. Lactobacillus salivarius BP121 prevents cisplatin‑induced acute kidney injury by inhibition of uremic toxins such as indoxyl sulfate and p‑cresol sulfate via alleviating dysbiosis. Int J Mol Med. 2020 Apr;45(4):1130-1140. doi: 10.3892/ijmm.2020.4495. Epub 2020 Feb 10. PMID: 32124946; PMCID: PMC7053870.