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MedKoo Cat#: 462038 | Name: TBI-223

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TBI-223 is a novel oxazolidinone. TBI-223 has shown activity against M.tb and is in development to treat TB. Linezolid, Sutezolid, and Cycloserine.

Chemical Structure

TBI-223
TBI-223
CAS#2071265-08-0

Theoretical Analysis

MedKoo Cat#: 462038

Name: TBI-223

CAS#: 2071265-08-0

Chemical Formula: C17H20FN3O5

Exact Mass: 365.1387

Molecular Weight: 365.36

Elemental Analysis: C, 55.89; H, 5.52; F, 5.20; N, 11.50; O, 21.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TBI-223; TBI 223
IUPAC/Chemical Name
Carbamic acid, N-(((5S)-3-(3-fluoro-4-(2-oxa-6-azaspiro(3.3)hept-6-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-, methyl ester
InChi Key
ZNBRXLSWXJKKLJ-LBPRGKRZSA-N
InChi Code
InChI=1S/C17H20FN3O5/c1-24-15(22)19-5-12-6-21(16(23)26-12)11-2-3-14(13(18)4-11)20-7-17(8-20)9-25-10-17/h2-4,12H,5-10H2,1H3,(H,19,22)/t12-/m0/s1
SMILES Code
O=C(OC)NC[C@H]1CN(C2=CC=C(N(C3)CC43COC4)C(F)=C2)C(O1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 365.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Antibiotics in the clinical pipeline in October 2019 Mark S. Butler, David L. Paterson J Antibiot (Tokyo) 2020; 73(6): 329–364. Published online 2020 Mar 10. doi: 10.1038/s41429-020-0291-8 PMCID: PMC7223789 2: Opportunities for Overcoming Mycobacterium tuberculosis Drug Resistance: Emerging Mycobacterial Targets and Host-Directed Therapy Eveline Torfs, Tatiana Piller, Paul Cos, Davie Cappoen Int J Mol Sci. 2019 Jun; 20(12): 2868. Published online 2019 Jun 12. doi: 10.3390/ijms20122868 PMCID: PMC6627145.