MedKoo Cat#: 534610 | Name: ADX68692

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ADX68692 is a novel nonsteroidal negative allosteric modulator of follicle-stimulating hormone receptor (FSHR).

Chemical Structure

ADX68692
CAS#1067191-08-5

Theoretical Analysis

MedKoo Cat#: 534610

Name: ADX68692

CAS#: 1067191-08-5

Chemical Formula: C24H23N3O3

Exact Mass: 401.1739

Molecular Weight: 401.47

Elemental Analysis: C, 71.80; H, 5.77; N, 10.47; O, 11.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ADX68692; ADX-68692; ADX 68692
IUPAC/Chemical Name
N-(4-(2-Cyanopropan-2-yl)-3-(pyridin-3-yl)phenyl)-3,4-dimethoxybenzamide
InChi Key
AMOZYIARVZBSIH-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H23N3O3/c1-24(2,15-25)20-9-8-18(13-19(20)17-6-5-11-26-14-17)27-23(28)16-7-10-21(29-3)22(12-16)30-4/h5-14H,1-4H3,(H,27,28)
SMILES Code
O=C(NC1=CC=C(C(C)(C#N)C)C(C2=CC=CN=C2)=C1)C3=CC=C(OC)C(OC)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 401.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dias JA, Campo B, Weaver BA, Watts J, Kluetzman K, Thomas RM, Bonnet B, Mutel V, Poli SM. Inhibition of follicle-stimulating hormone-induced preovulatory follicles in rats treated with a nonsteroidal negative allosteric modulator of follicle-stimulating hormone receptor. Biol Reprod. 2014 Jan 30;90(1):19. doi: 10.1095/biolreprod.113.109397. PMID: 24285717; PMCID: PMC4435417. 2: Ayoub MA, Yvinec R, Jégot G, Dias JA, Poli SM, Poupon A, Crépieux P, Reiter E. Profiling of FSHR negative allosteric modulators on LH/CGR reveals biased antagonism with implications in steroidogenesis. Mol Cell Endocrinol. 2016 Nov 15;436:10-22. doi: 10.1016/j.mce.2016.07.013. Epub 2016 Jul 14. PMID: 27424143.