Synonym
Bamirastine; TAK 427; TAK-427
IUPAC/Chemical Name
2-(6-((3-(4-(Diphenylmethoxy)piperidin-1-yl)propyl)amino)imidazo(1,2-b)pyridazin-2-yl)-2-methylpropanoic acid
InChi Key
WTBRUSNNZKWTMI-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H37N5O3/c1-31(2,30(37)38)26-22-36-28(33-26)15-14-27(34-36)32-18-9-19-35-20-16-25(17-21-35)39-29(23-10-5-3-6-11-23)24-12-7-4-8-13-24/h3-8,10-15,22,25,29H,9,16-21H2,1-2H3,(H,32,34)(H,37,38)
SMILES Code
CC(C)(C1=CN2N=C(NCCCN3CCC(OC(C4=CC=CC=C4)C5=CC=CC=C5)CC3)C=CC2=N1)C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
527.67
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Oxazolone-Induced Delayed Type Hypersensitivity Reaction in the Adult Yucatan Pigs. A Useful Model for Drug Development and Validation Samer Nuhaily, Bassam B. Damaj, Azzam A. Maghazachi Toxins (Basel) 2009 Sep; 1(1): 25–36. Published online 2009 Aug 21. doi: 10.3390/toxins1010025 PMCID: PMC3202774
2: Effects of Bifidobacterium bifidum G9-1 on Nasal Symptoms in a Guinea Pig Model of Experimental Allergic Rhinitis Satoru TSUNEMINE, Yasuhiro ISA, Masaki SHIMAKAWA, Hiroshi OHNO, Hideki YAMAMURA Biosci Microflora. 2011; 30(1): 1–7. Published online 2010 Feb 18. doi: 10.12938/bifidus.30.1 PMCID: PMC4103633
3: NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammation Delong Jiao, Chun-Kwok Wong, Huai-Na Qiu, Jie Dong, Zhe Cai, Man Chu, Kam-Lun Hon, Miranda Sin-Man Tsang, Christopher Wai-Kei Lam Cell Mol Immunol. 2016 Jul; 13(4): 535–550. Published online 2015 Sep 21. doi: 10.1038/cmi.2015.77 PMCID: PMC4947824
4: Herbex-kid Inhibits Immediate Hypersensitivity Reactions in Mice and Rats Anil Kumar, Rawal Prasad, Nanjan Mulla Jogge, Suresh Bhojraj, Solomon F. Emerson, S. Prabakar Evid Based Complement Alternat Med. 2008 Sep; 5(3): 289–294. Published online 2007 May 17. doi: 10.1093/ecam/nem034 PMCID: PMC2529394
