Tacapenem | CAS#193811-33-5 | carbapenem antibiotic

MedKoo Cat#: 462013 | Name: Tacapenem

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tacapenem is a carbapenem antibiotic.

Chemical Structure

Tacapenem

CAS#193811-33-5

Theoretical Analysis

MedKoo Cat#: 462013

Name: Tacapenem

CAS#: 193811-33-5

Chemical Formula: C14H18N2O5S

Exact Mass: 326.0936

Molecular Weight: 326.37

Elemental Analysis: C, 51.52; H, 5.56; N, 8.58; O, 24.51; S, 9.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Tacapenem; R 95867

IUPAC/Chemical Name

( )-(4R,5S,6S)-6-((1R)-1-Hydroxyethyl)-4-methyl-7-oxo-3-(((3R)-5-oxopyrrolidin-3-yl)sulfanyl)-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid

InChi Key

CTEFNVKDRWMZSL-CTNSIQBBSA-N

InChi Code

InChI=1S/C14H18N2O5S/c1-5-10-9(6(2)17)13(19)16(10)11(14(20)21)12(5)22-7-3-8(18)15-4-7/h5-7,9-10,17H,3-4H2,1-2H3,(H,15,18)(H,20,21)/t5-,6-,7-,9-,10-/m1/s1

SMILES Code

O=C(C(N12)=C(S[C@H](C3)CNC3=O)[C@H](C)[C@]2([H])[C@@H]([C@H](O)C)C1=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 326.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: In vitro and in vivo antibacterial activities of CS-834, a novel oral carbapenem. T Fukuoka, S Ohya, Y Utsui, H Domon, T Takenouchi, T Koga, N Masuda, H Kawada, M Kakuta, M Kubota, C Ishii, C Ishii, E Sakagawa, T Harasaki, A Hirasawa, T Abe, H Yasuda, M Iwata, S Kuwahara Antimicrob Agents Chemother. 1997 Dec; 41(12): 2652–2663. PMCID: PMC164185 2: Safety and pharmacokinetics of CS-834, a new oral carbapenem antibiotic, in healthy volunteers. K Umemura, Y Ikeda, K Kondo, M Nakashima, H Naganuma, M Hisaoka, H Nishino, M Tajima Antimicrob Agents Chemother. 1997 Dec; 41(12): 2664–2669. PMCID: PMC164186 3: In Vitro and In Vivo Antibacterial Activities of CS-834, a New Oral Carbapenem Keizo Yamaguchi, Haruki Domon, Shuichi Miyazaki, Kazuhiro Tateda, Akira Ohno, Kazuhiro Ishii, Tetsuya Matsumoto, Nobuhiko Furuya Antimicrob Agents Chemother. 1998 Mar; 42(3): 555–563. Correction in: Antimicrob Agents Chemother. 1998 Jun; 42(6): 1527. PMCID: PMC105498 4: Efficacy of CS-834 against Experimental Pneumonia Caused by Penicillin-Susceptible and -Resistant Streptococcus pneumoniae in Mice Takashi Fukuoka, Harumi Kawada, Akiko Kitayama, Tetsufumi Koga, Mikie Kubota, Tamako Harasaki, Yasuki Kamai, Satoshi Ohya, Hiroshi Yasuda, Masayuki Iwata, Shogo Kuwahara Antimicrob Agents Chemother. 1998 Jan; 42(1): 23–27. PMCID: PMC105450 5: Hypersusceptibility of the Pseudomonas aeruginosa nfxB Mutant to β-Lactams Due to Reduced Expression of the AmpC β-Lactamase Nobuhisa Masuda, Eiko Sakagawa, Satoshi Ohya, Naomasa Gotoh, Takeshi Nishino Antimicrob Agents Chemother. 2001 Apr; 45(4): 1284–1286. doi: 10.1128/AAC.45.4.1284-1286.2001 PMCID: PMC90457