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MedKoo Cat#: 462010 | Name: Tac 278

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tac 278 is a prodrug of 5-fluorouracil.

Chemical Structure

Tac 278
Tac 278
CAS#65906-75-4

Theoretical Analysis

MedKoo Cat#: 462010

Name: Tac 278

CAS#: 65906-75-4

Chemical Formula: C11H17FN2O5

Exact Mass: 276.1121

Molecular Weight: 276.26

Elemental Analysis: C, 47.82; H, 6.20; F, 6.88; N, 10.14; O, 28.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tac 278, Tac-278; NSC 375520
IUPAC/Chemical Name
ethyl 4-butoxy-5-fluoro-2,6-dioxo-1,3-diazinane-5-carboxylate
InChi Key
QYIJQWZDUJULHZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H17FN2O5/c1-3-5-6-19-8-11(12,9(16)18-4-2)7(15)13-10(17)14-8/h8H,3-6H2,1-2H3,(H2,13,14,15,17)
SMILES Code
O=C(C1(F)C(OCCCC)NC(NC1=O)=O)OCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 276.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: NFKB1 Promoter DNA from nt+402 to nt+99 Is Hypomethylated in Different Human Immune Cells Matthias Unterberg, Maxmiliane Julia Kreuzer, Simon Thomas Schäfer, Zainab Bazzi, Michael Adamzik, Katharina Rump PLoS One. 2016; 11(6): e0156702. Published online 2016 Jun 1. doi: 10.1371/journal.pone.0156702 PMCID: PMC4889142 2: Cloning, sequence and expression of rat cathepsin D. N P Birch, Y P Loh Nucleic Acids Res. 1990 Nov 11; 18(21): 6445–6446. doi: 10.1093/nar/18.21.6445 PMCID: PMC332560 3: Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing Stefan Taudien, Marco Groth, Klaus Huse, Andreas Petzold, Karol Szafranski, Jochen Hampe, Philip Rosenstiel, Stefan Schreiber, Matthias Platzer BMC Genomics. 2010; 11: 252. Published online 2010 Apr 19. doi: 10.1186/1471-2164-11-252 PMCID: PMC2873476