Sulfadiazine sodium | CAS#547-32-0 | Sulfonamide

MedKoo Cat#: 534588 | Name: Sulfadiazine sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sulfadiazine sodium is one of the short-acting sulfonamide used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.

Chemical Structure

Sulfadiazine sodium

CAS#547-32-0 (Salt)

Theoretical Analysis

MedKoo Cat#: 534588

Name: Sulfadiazine sodium

CAS#: 547-32-0 (Salt)

Chemical Formula: C10H9N4NaO2S

Exact Mass: 272.0344

Molecular Weight: 272.26

Elemental Analysis: C, 44.12; H, 3.33; N, 20.58; Na, 8.44; O, 11.75; S, 11.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

68-35-9; 547-32-0 (Salt)

Synonym

Sulfadiazine sodium; NSC117870; NSC-117870; NSC 117870; Soludiazine; Sulphadiazine; Suthogen

IUPAC/Chemical Name

Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, monosodium salt

InChi Key

JLDCNMJPBBKAHH-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H9N4O2S.Na/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1

SMILES Code

O=S(C1=CC=C(N)C=C1)([N-]C2=NC=CC=N2)=O.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 272.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Naser NA, Alasedi KM, Khan ZA. New approach for determination of sulfadiazine in pharmaceutical preparations using 4(4-sulphophenylazo)pyrogallol: Kinetic spectrophotometric method. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Aug 5;201:267-280. doi: 10.1016/j.saa.2018.05.012. Epub 2018 May 4. PMID: 29758513. 2: Berns AE, Philipp H, Lewandowski H, Choi JH, Lamshöft M, Narres HD. Interactions of 15N-Sulfadiazine and Soil Components As Evidenced by 15N-CPMAS NMR. Environ Sci Technol. 2018 Mar 20;52(6):3748-3757. doi: 10.1021/acs.est.7b06164. Epub 2018 Mar 1. PMID: 29465228. 3: Ventura MG, Wybran J, Farber CM. Sulfadiazine revisited. J Infect Dis. 1989 Sep;160(3):556-7. doi: 10.1093/infdis/160.3.556. PMID: 2760508. 4: Delrivo A, Aloisio C, Longhi MR, Granero G. Artificial Lipid Membrane Permeability Method for Predicting Intestinal Drug Transport: Probing the Determining Step in the Oral Absorption of Sulfadiazine; Influence of the Formation of Binary and Ternary Complexes with Cyclodextrins. AAPS PharmSciTech. 2018 Apr;19(3):1437-1447. doi: 10.1208/s12249-018-0965-8. Epub 2018 Feb 15. PMID: 29450829. 5: Vione D, Fabbri D, Minella M, Canonica S. Effects of the antioxidant moieties of dissolved organic matter on triplet-sensitized phototransformation processes: Implications for the photochemical modeling of sulfadiazine. Water Res. 2018 Jan 1;128:38-48. doi: 10.1016/j.watres.2017.10.020. Epub 2017 Oct 9. PMID: 29078069. 6: Hoffmann S. Silver sulfadiazine: an antibacterial agent for topical use in burns. A review of the literature. Scand J Plast Reconstr Surg. 1984;18(1):119-26. doi: 10.3109/02844318409057413. PMID: 6377481. 7: Graves RA, Phan KV, Bostanian LA, Mandal TK, Pramar YV. Physicochemical Stability of an Oral Suspension of Trimethoprim 20 mg/mL in Combination with Sulfadiazine 200 mg/mL in PCCA Base SuspendIt. Int J Pharm Compd. 2017 Sep- Oct;21(5):430-435. PMID: 29216620. 8: Chen J, Jiang X, Tong T, Miao S, Huang J, Xie S. Sulfadiazine degradation in soils: Dynamics, functional gene, antibiotic resistance genes and microbial community. Sci Total Environ. 2019 Nov 15;691:1072-1081. doi: 10.1016/j.scitotenv.2019.07.230. Epub 2019 Jul 16. PMID: 31466189. 9: Ahmed MT, Naqvi SAR, Rasheed R, Zahoor AF, Usman M, Hussain Z. Technetium-99m-Labeled Sulfadiazine: a Targeting Radiopharmaceutical for Scintigraphic Imaging of Infectious Foci Due To Escherichia coli in Mouse and Rabbit Models. Appl Biochem Biotechnol. 2017 Sep;183(1):374-384. doi: 10.1007/s12010-017-2451-2. Epub 2017 Mar 11. PMID: 28285355. 10: Zhang C, Hu L, Ding X, Lu Y, Hu G. The Role of Sulfadiazine for the Treatment of Refractory Intracranial Infection. Turk Neurosurg. 2015;25(6):895-9. doi: 10.5137/1019-5149.JTN.11920-14.1. PMID: 26617139.