Synonym
6-Chloroguanine; 2-Amino-6-chloropurine; NSC 29570; 6-Chloro-1H-purin-2-amine
IUPAC/Chemical Name
1H-Purin-2-amine, 6-chloro- (9CI)
InChi Key
RYYIULNRIVUMTQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
SMILES Code
NC1=NC2=NC=NC2=C(Cl)N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
169.57
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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6: Keough DT, Skinner-Adams T, Jones MK, Ng AL, Brereton IM, Guddat LW, de Jersey J. Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases. J Med Chem. 2006 Dec 14;49(25):7479-86. PubMed PMID: 17149876.
7: Mondal S, Puranik M. Ultrafast structural dynamics of photoexcited adenine. Phys Chem Chem Phys. 2017 Aug 2;19(30):20224-20240. doi: 10.1039/c7cp03092d. PubMed PMID: 28726897.
8: Mahajan TR, Ytre-Arne ME, Strøm-Andersen P, Dalhus B, Gundersen LL. Synthetic Routes to N-9 Alkylated 8-Oxoguanines; Weak Inhibitors of the Human DNA Glycosylase OGG1. Molecules. 2015 Sep 2;20(9):15944-65. doi:10.3390/molecules200915944. PubMed PMID: 26364627; PubMed Central PMCID: PMC6332111.
9: Kröplin T, Fischer C, Iven H. Inhibition of thiopurine S-methyltransferase activity by impurities in commercially available substrates: a factor for differing results of TPMT measurements. Eur J Clin Pharmacol. 1999 Jun;55(4):285-91. PubMed PMID: 10424321.
10: Ashby J, Paton D, Styles JA, Greatbanks D, Wright B. Synthesis of N7-hydroxyethylguanine and O6-hydroxyethylguanine. Markers for the reaction of ethylene oxide (EO) with DNA. Mutat Res. 1982 Mar;103(3-6):257-61. PubMed PMID:7087988.
11: Wang X, Qiu H, Liu X, Jiang S. [Separation of bases, phenols and pharmaceuticals on ionic liquid-modified silica stationary phase with pure water as mobile phase]. Se Pu. 2011 Mar;29(3):269-72. Chinese. PubMed PMID: 21657060
