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MedKoo Cat#: 461962 | Name: Sdk 12B-5

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sdk 12B-5 is a a novel antitumor agent. Maximum chemotherapeutic effect is obtained when SDK-12B-5 is administered p.o. repeatedly with every other day to avoid the cumulative toxicity.

Chemical Structure

Sdk 12B-5
Sdk 12B-5
CAS#103579-36-8

Theoretical Analysis

MedKoo Cat#: 461962

Name: Sdk 12B-5

CAS#: 103579-36-8

Chemical Formula: C17H22FN3O3SSi

Exact Mass: 395.1135

Molecular Weight: 395.52

Elemental Analysis: C, 51.62; H, 5.61; F, 4.80; N, 10.62; O, 12.14; S, 8.11; Si, 7.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Sdk 12B-5; SDK 12B5
IUPAC/Chemical Name
5-fluoro-3,4-dihydro-2,4-dioxo-N-[2-2- (dimethylphenylsilyl)ethylthioethyl]-1(2H)-pyrimidinocarb oxamide
InChi Key
AJSCIXMGTRAODP-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H22FN3O3SSi/c1-26(2,13-6-4-3-5-7-13)11-10-25-9-8-19-16(23)21-12-14(18)15(22)20-17(21)24/h3-7,12H,8-11H2,1-2H3,(H,19,23)(H,20,22,24)
SMILES Code
O=C(N(C(N1)=O)C=C(F)C1=O)NCCSCC[Si](C)(C)C2=CC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 395.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fukushima K. [Antitumor effects of 5-fluorouracil-bound organic silicon compound]. Gan To Kagaku Ryoho. 1989 Sep;16(9):3243-50. Japanese. PubMed PMID:2782916.