INH154 | CAS#1587705-63-2

MedKoo Cat#: 408093 | Name: INH154

Description:

WARNING: This product is for research use only, not for human or veterinary use.

INH154 is a novel small molecules disrupting Hec1/Nek2 interaction, inhibits HeLa and MDA-MB-468 cancer cells growth with IC50 of 0.20 and 0.12 uM, respectively. INH154, is highly potent in treating breast tumors with co-elevated expression of Hec1 and Nek2. INH154 suppressed the growth of leukemia, osteosarcoma, and glioblastoma cells, but had no significant growth inhibitory effects on non-tumorigenic fibroblast, HS27 and mammary epithelial cell, MCF10A. INH154 effectively inhibited cancer cell growth in a dose-dependent manner

Chemical Structure

INH154

CAS#1587705-63-2

Theoretical Analysis

MedKoo Cat#: 408093

Name: INH154

CAS#: 1587705-63-2

Chemical Formula: C22H24N4OS

Exact Mass: 392.1671

Molecular Weight: 392.52

Elemental Analysis: C, 67.32; H, 6.16; N, 14.27; O, 4.08; S, 8.17

Price and Availability

Size	Price	Availability
1g	USD 2,950.00	4~6 Weeks
2g	USD 4,950.00	4~6 Weeks
5g	USD 6,850.00	4~6 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

INH154; INH-154; INH 154; BP-001; BP001; BP 001;

IUPAC/Chemical Name

N-(4-(2,6-dimethyl-4-(piperidin-1-yl)phenyl)thiazol-2-yl)isonicotinamide

InChi Key

BBVORAZSFSZSKG-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H24N4OS/c1-15-12-18(26-10-4-3-5-11-26)13-16(2)20(15)19-14-28-22(24-19)25-21(27)17-6-8-23-9-7-17/h6-9,12-14H,3-5,10-11H2,1-2H3,(H,24,25,27)

SMILES Code

O=C(NC1=NC(C2=C(C)C=C(N3CCCCC3)C=C2C)=CS1)C4=CC=NC=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

INH154 is a highly potent inhibitor for Nek2 and Hec1 binding (INH), with IC50s of 200 nM and 120 nM for INH in Hela and MB468 cells.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	81.2	206.78
	Ethanol	5.0	12.74

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 392.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

Hu CM, Zhu J, Guo XE, et al. Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism. Oncogene. 2015;34(10):1220‐1230. doi:10.1038/onc.2014.67