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MedKoo Cat#: 555755 | Name: PKG Drug G1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PKG drug G1 is an activator of protein kinase GIα (PKGIα).

Chemical Structure

PKG Drug G1
PKG Drug G1
CAS#374703-78-3

Theoretical Analysis

MedKoo Cat#: 555755

Name: PKG Drug G1

CAS#: 374703-78-3

Chemical Formula: C13H11N3OS

Exact Mass: 257.0623

Molecular Weight: 257.31

Elemental Analysis: C, 60.68; H, 4.31; N, 16.33; O, 6.22; S, 12.46

Price and Availability

Size Price Availability Quantity
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 1,950.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 5,250.00 2 Weeks
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Related CAS #
No Data
Synonym
PKG Drug G1
IUPAC/Chemical Name
5-[(2-methyl-1H-indol-3-yl)methylene]-2-thioxo-4-imidazolidinone
InChi Key
SNLLEQAPNVMOOT-WDZFZDKYSA-N
InChi Code
InChI=1S/C13H11N3OS/c1-7-9(6-11-12(17)16-13(18)15-11)8-4-2-3-5-10(8)14-7/h2-6,14H,1H3,(H2,15,16,17,18)/b11-6-
SMILES Code
O=C(/C(N1)=C/C2=C(C)NC3=C2C=CC=C3)NC1=S
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
PKG agent G1 targets C42 of PKG Iα.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
DMF 25.0 97.16
DMSO 48.7 189.14
Ethanol 3.0 11.66
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 257.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1. Burgoyne, J.R., Prysyazhna, O., Richards, D.A., et al. Proof of principle for a novel class of antihypertensives that target the oxidative activation of PKG Iα (protein kinase G Iα). Hypertension 70(3), 577-586 (2017).