ML239 is a potent and selective inhibitor of breast cancer stem cells. ML239 was best-in-class with an IC(50)= 1.18 µM against HMLE_sh_ECad, demonstrated a >23-fold selectivity over the control line, and was toxic to another CSC-like line, HMLE_shTwist, and a breast carcinoma cell line, MDA-MB-231. Gene expression studies conducted with ML239-treated cells showed altered gene expression in the NF-κB pathway in the HMLE_sh_ECad line but not in the isogenic control line.
MedKoo Cat#: 408083
Name: ML239
CAS#: 1378872-36-6
Chemical Formula: C13H10Cl3N3O2
Exact Mass: 344.9839
Molecular Weight: 346.59
Elemental Analysis: C, 45.05; H, 2.91; Cl, 30.68; N, 12.12; O, 9.23
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| Ethanol | 17.3 | 50.00 |
The following data is based on the product molecular weight 346.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
