C-DIM5, also known as DIM-C-pPhOCH3, is a synthetic diindolylmethane derivative and an agonist of the orphan nuclear receptor Nur77 (NR4A1). It selectively activates Nur77 over peroxisome proliferator-activated receptor gamma (PPARγ) in reporter assays at a concentration of 20 µM. In vitro studies have demonstrated that C-DIM5 inhibits growth and induces apoptosis in various cancer cell lines, including RKO colon cancer cells and L3.6pL pancreatic cancer cells, at concentrations ranging from 10 to 20 µM. Additionally, in vivo experiments have shown that C-DIM5, administered at 25 mg/kg/day, inhibits tumor growth in athymic nude mice bearing RKO cell xenografts.
MedKoo Cat#: 555753
Name: C-DIM5
CAS#: 33985-68-1
Chemical Formula: C24H20N2O
Exact Mass: 352.1576
Molecular Weight: 352.44
Elemental Analysis: C, 81.79; H, 5.72; N, 7.95; O, 4.54
The following data is based on the product molecular weight 352.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
