MRS7591 is a Partial Agonists at Mouse and Human A3 Adenosine Receptors with Ki = 10.9/17.8 nM, at human/mouse A3AR. MRS7591 was a partial agonist in vitro (hA3AR, cAMP inhibition, 31% Emax; mA3AR, [35S]GTP-γ-S binding, 16% Emax) and in vivo and also antagonized hA3AR in vitro. Highly potent and selective MRS7591 displayed A3AR antagonist as well as partial agonist properties in cells (both h and m) and maintained in vivo agonism in the mouse over a >2 h period and can be considered a useful tool compound for in vivo use.
MedKoo Cat#: 555748
Name: MRS7591
CAS#: Unknown
Chemical Formula: C28H27N5O4
Exact Mass: 497.2063
Molecular Weight: 497.56
Elemental Analysis: C, 67.59; H, 5.47; N, 14.08; O, 12.86
The following data is based on the product molecular weight 497.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
