MedKoo Cat#: 408081 | Name: CCT369260
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CCT369260 is a potent BCL6 degrader.

Chemical Structure

CCT369260
CAS#2253878-44-1

Theoretical Analysis

MedKoo Cat#: 408081

Name: CCT369260

CAS#: 2253878-44-1

Chemical Formula: C24H31ClF2N6O2

Exact Mass: 508.2165

Molecular Weight: 509.00

Elemental Analysis: C, 56.63; H, 6.14; Cl, 6.96; F, 7.47; N, 16.51; O, 6.29

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
25mg USD 1,450.00 2 Weeks
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Related CAS #
No Data
Synonym
CCT369260; CCT-369260; CCT 369260;
IUPAC/Chemical Name
5-((5-chloro-2-((3R,5S)-4,4-difluoro-3,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-3-(3-hydroxy-3-methylbutyl)-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one
InChi Key
VFNPUAOAEFMXQI-GASCZTMLSA-N
InChi Code
InChI=1S/C24H31ClF2N6O2/c1-14-12-32(13-15(2)24(14,26)27)21-28-11-17(25)20(30-21)29-16-6-7-18-19(10-16)33(22(34)31(18)5)9-8-23(3,4)35/h6-7,10-11,14-15,35H,8-9,12-13H2,1-5H3,(H,28,29,30)/t14-,15+
SMILES Code
O=C1N(C)C2=CC=C(NC3=NC(N4C[C@@H](C)C(F)(F)[C@@H](C)C4)=NC=C3Cl)C=C2N1CCC(C)(O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Deregulation of the transcriptional repressor BCL6 enables tumorigenesis of germinal center B-cells, and hence BCL6 has been proposed as a therapeutic target for the treatment of diffuse large B-cell lymphoma (DLBCL).

Preparing Stock Solutions

The following data is based on the product molecular weight 509.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders Benjamin R. BellenieKwai-Ming J. CheungAna VarelaOlivier A. PierratGavin W. CollieGary M. BoxMichael D. BrightSharon GowanAngela HayesMatthew J. RodriguesKartika N. ShettyMichael CarterOwen A. DavisAlan T. HenleyPaolo InnocentiLouise D. JohnsonManjuan LiuSelby de KlerkYann-Vaï Le BihanMatthew G. LloydP. Craig McAndrewErald ShehuRachel TalbotHannah L. WoodwardRosemary BurkeVladimir KirkinRob L. M. van MontfortFlorence I. RaynaudOlivia W. RossaneseSwen Hoelder* Journal of Medicinal Chemistry, Articles ASAP (Article)ACS AuthorChoice Publication Date (Web):April 10, 2020