Synonym
Danshenxinkun A; Tanshinone VI;
IUPAC/Chemical Name
1-hydroxy-2-(1-hydroxypropan-2-yl)-8-methylphenanthrene-3,4-dione
InChi Key
GRGPQNRHXNRJFL-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H16O4/c1-9-4-3-5-12-11(9)6-7-13-15(12)18(22)17(21)14(16(13)20)10(2)8-19/h3-7,10,19-20H,8H2,1-2H3
SMILES Code
O=C1C(C(C)CO)=C(O)C2=C(C3=C(C=C2)C(C)=CC=C3)C1=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Danshenxinkun A is a natural compound that could be isolated from Tanshen and is used in the study for heart diseases.
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
0.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
296.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Li B, Wu YR, Li L, Liu Y, Yan ZY. A Novel Based-Network Strategy to Identify Phytochemicals from Radix Salviae Miltiorrhizae (Danshen) for Treating Alzheimer's Disease. Molecules. 2022 Jul 12;27(14):4463. doi: 10.3390/molecules27144463. PMID: 35889336; PMCID: PMC9317794.
2: Lin HC, Ding HY, Chang WL. Two new fatty diterpenoids from Salvia miltiorrhiza. J Nat Prod. 2001 May;64(5):648-50. doi: 10.1021/np000345v. PMID: 11374966.
3: Li HB, Chen F. Preparative isolation and purification of six diterpenoids from the Chinese medicinal plant Salvia miltiorrhiza by high-speed counter- current chromatography. J Chromatogr A. 2001 Aug 3;925(1-2):109-14. doi: 10.1016/s0021-9673(01)01026-3. PMID: 11519796.
4: Luo HW, Wu BJ, Wu MY, Yong ZG, Jin Y. [Isolation and structure of danshenxinkun D]. Yao Xue Xue Bao. 1985 Jul;20(7):542-4. Chinese. PMID: 3841630.
5: Wang HQ, Yang LX, Chen XY, Yang PF, Chen RY. [Chemical Constituents from Salvia przewalskii Root]. Zhong Yao Cai. 2015 Jun;38(6):1197-201. Chinese. PMID: 26762059.
6: Jiang R, Zhang X, Li Y, Zhou H, Wang H, Wang F, Ma H, Cao L. Identification of the molecular mechanisms of Salvia miltiorrhiza relevant to the treatment of osteoarthritis based on network pharmacology. Discov Med. 2020 Sep- Oct;30(160):83-95. PMID: 33382964.
7: Lin LZ, Wang XM, Huang XL, Huang Y, Yang BJ. [A new diterpenoid quinone dehydromiltirone]. Yao Xue Xue Bao. 1988 Apr;23(4):273-5. Chinese. PMID: 3176980.
8: Shu Y, Zhu W, Hu Q. [Chemical constituents of tissue cultures of Salvia miltiorrhiza Bunge]. Zhongguo Zhong Yao Za Zhi. 1998 Mar;23(3):166-7, 192. Chinese. PMID: 11596236.
9: Liu M, Li YG, Zhang F, Yang L, Chou GX, Wang ZT, Hu ZB. Chromatographic fingerprinting analysis of Danshen root (Salvia miltiorrhiza Radix et Rhizoma) and its preparations using high performance liquid chromatography with diode array detection and electrospray mass spectrometry (HPLC-DAD-ESI/MS). J Sep Sci. 2007 Sep;30(14):2256-67. doi: 10.1002/jssc.200700149. PMID: 17683043.
