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MedKoo Cat#: 533996 | Name: Acetochlor
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Acetochlor is one of the most widely used pesticides worldwide to control broadleaf weeds and widely distributed in the water environment. Low-dose acetochlor had estrogen effect and induced zebrafish estradiol (E2) and ovarian vitellogenin (Vtg) synthesis and promoted ovarian development, while long-term exposure to higher doses of acetochlor reduced the ability of ovarian resistance to oxidative stress and destroyed the development of the ovary.

Chemical Structure

Acetochlor
Acetochlor
CAS#34256-82-1

Theoretical Analysis

MedKoo Cat#: 533996

Name: Acetochlor

CAS#: 34256-82-1

Chemical Formula: C14H20ClNO2

Exact Mass: 269.1183

Molecular Weight: 269.77

Elemental Analysis: C, 62.33; H, 7.47; Cl, 13.14; N, 5.19; O, 11.86

Price and Availability

Size Price Availability Quantity
50mg USD 250.00 2 Weeks
100mg USD 450.00 2 Weeks
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Related CAS #
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Synonym
Acetochlor
IUPAC/Chemical Name
Acetamide, 2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methylphenyl)- (9CI)
InChi Key
VTNQPKFIQCLBDU-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H20ClNO2/c1-4-12-8-6-7-11(3)14(12)16(10-18-5-2)13(17)9-15/h6-8H,4-5,9-10H2,1-3H3
SMILES Code
O=C(N(COCC)C1=C(C)C=CC=C1CC)CCl
Appearance
Liquid
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 269.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Qin X, Jiang Y, Wang Z, Man C, Fu S, Chen S, Yang X, Yang T, Zhang D, Li L, Fox EM, Zhang W. The migration of acetochlor from feed to milk. RSC Adv. 2020 Dec 15;10(72):44344-44351. doi: 10.1039/d0ra06895k. PMID: 35517176; PMCID: PMC9058494. 2: Zhang Y, Xue W, Long R, Yang H, Wei W. Acetochlor affects zebrafish ovarian development by producing estrogen effects and inducing oxidative stress. Environ Sci Pollut Res Int. 2020 Aug;27(22):27688-27696. doi: 10.1007/s11356-020-09050-2. Epub 2020 May 11. PMID: 32394252. 3: Lu Q, Shen Z, Zheng K, Chang Q, Xue J, Wu X. Estimating the bioavailability of acetochlor to wheat using in situ pore water and passive sampling. Sci Total Environ. 2022 Aug 10;833:155239. doi: 10.1016/j.scitotenv.2022.155239. Epub 2022 Apr 11. PMID: 35421494. 4: Zhao X, Shi X, Liu Q, Li X. Tea polyphenols alleviates acetochlor-induced apoptosis and necroptosis via ROS/MAPK/NF-κB signaling in Ctenopharyngodon idellus kidney cells. Aquat Toxicol. 2022 May;246:106153. doi: 10.1016/j.aquatox.2022.106153. Epub 2022 Mar 28. PMID: 35381412. 5: Mahmood Y, Hussain R, Ghaffar A, Ali F, Nawaz S, Mehmood K, Khan A. Acetochlor Affects Bighead Carp (Aristichthys Nobilis) by Producing Oxidative Stress, Lowering Tissue Proteins, and Inducing Genotoxicity. Biomed Res Int. 2022 May 23;2022:9140060. doi: 10.1155/2022/9140060. PMID: 35655481; PMCID: PMC9152400. 6: Liu J, Zhang X, Xu J, Qiu J, Zhu J, Cao H, He J. Anaerobic biodegradation of acetochlor by acclimated sludge and its anaerobic catabolic pathway. Sci Total Environ. 2020 Dec 15;748:141122. doi: 10.1016/j.scitotenv.2020.141122. Epub 2020 Jul 24. PMID: 32810802. 7: Liu J, Zhao S, Wu N, Hu G, Qiu J, He J, Qiao W. Sulfate-Dependent Anaerobic Degradation of Herbicide Acetochlor by a Sulfate-Reducing Bacterium Cupidesulfovibrio sp. SRB-5. J Agric Food Chem. 2022 Oct 19;70(41):13340-13348. doi: 10.1021/acs.jafc.2c03327. Epub 2022 Oct 5. PMID: 36198124. 8: Huang T, Huang Y, Huang Y, Yang Y, Zhao Y, Martyniuk CJ. Toxicity assessment of the herbicide acetochlor in the human liver carcinoma (HepG2) cell line. Chemosphere. 2020 Mar;243:125345. doi: 10.1016/j.chemosphere.2019.125345. Epub 2019 Nov 9. PMID: 31739254. 9: Chen MY, Zhang H, Huo ZL, Chen H, Dou JR, Zhu BL, Zhang F. [Determination of acetochlor and its metabolites in urine using liquid chromatography-tandem mass spectrometry]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2022 May 20;40(5):373-377. Chinese. doi: 10.3760/cma.j.cn121094-20210917-00464. PMID: 35680583. 10: Chu C, Liu B, Liu J, He J, Lv L, Wang H, Xie X, Tao Q, Chen Q. Phytoremediation of acetochlor residue by transgenic Arabidopsis expressing the acetochlor N-dealkylase from Sphingomonas wittichii DC-6. Sci Total Environ. 2020 Aug 1;728:138687. doi: 10.1016/j.scitotenv.2020.138687. Epub 2020 Apr 14. PMID: 32361114. 11: Li H, Wang Y, Fu J, Hu S, Qu J. Degradation of acetochlor and beneficial effect of phosphate-solubilizing Bacillus sp. ACD-9 on maize seedlings. 3 Biotech. 2020 Feb;10(2):67. doi: 10.1007/s13205-020-2056-2. Epub 2020 Jan 24. PMID: 32030336; PMCID: PMC6981330. 12: Zhang N, Xie F, Guo QN, Yang H. Environmental disappearance of acetochlor and its bioavailability to weed: A general prototype for reduced herbicide application instruction. Chemosphere. 2021 Feb;265:129108. doi: 10.1016/j.chemosphere.2020.129108. Epub 2020 Nov 26. PMID: 33277001. 13: Yang J, Cheng X, Zhang S, Ye Q. Superabsorbent hydrogel as a formulation to promote mineralization and accelerate degradation of acetochlor in soils. J Hazard Mater. 2022 Oct 15;440:129777. doi: 10.1016/j.jhazmat.2022.129777. Epub 2022 Aug 18. PMID: 36007361. 14: Ju C, Zhang H, Wu R, Dong S, Yao S, Wang F, Cao D, Xu S, Fang H, Yu Y. Upward translocation of acetochlor and atrazine in wheat plants depends on their distribution in roots. Sci Total Environ. 2020 Feb 10;703:135636. doi: 10.1016/j.scitotenv.2019.135636. Epub 2019 Nov 20. PMID: 31771841. 15: Rollerova E, Wsolova L, Urbancikova M. Herbicide acetochlor interferes with proliferation activity of MCF-7 cells enhanced by estradiol. Endocr Regul. 2014 Oct;48(4):195-200. doi: 10.4149/endo_2014_04_195. PMID: 25512193. 16: Huang T, Wang S, Souders CL 2nd, Ivantsova E, Wengrovitz A, Ganter J, Zhao YH, Cheng H, Martyniuk CJ. Exposure to acetochlor impairs swim bladder formation, induces heat shock protein expression, and promotes locomotor activity in zebrafish (Danio rerio) larvae. Ecotoxicol Environ Saf. 2021 Nov 15;228:112978. doi: 10.1016/j.ecoenv.2021.112978. Epub ahead of print. PMID: 34794026. 17: An W, Sang C, Jensen KM, Sørensen PB, Zhang B, Yang M. Application of the health risk assessment of acetochlor in the development of water quality criteria. J Environ Sci (China). 2021 Dec;110:48-54. doi: 10.1016/j.jes.2021.03.014. Epub 2021 Apr 17. PMID: 34593194. 18: Wang H, Meng Z, Zhou L, Cao Z, Liao X, Ye R, Lu H. Effects of acetochlor on neurogenesis and behaviour in zebrafish at early developmental stages. Chemosphere. 2019 Apr;220:954-964. doi: 10.1016/j.chemosphere.2018.12.199. Epub 2019 Jan 2. PMID: 33395817. 19: Li X, Bai R, Bai Y, Shi X, Yang Y, Xu S. ROS-mediated PPAR/RXR inhibition contributes to acetochlor-induced apoptosis and autophagy in Ctenopharyngodon idella hepatic cells. Fish Shellfish Immunol. 2022 Sep;128:684-694. doi: 10.1016/j.fsi.2022.08.053. Epub 2022 Aug 24. PMID: 36028057. 20: Luo W, Gu Q, Chen W, Zhu X, Duan Z, Yu X. Biodegradation of acetochlor by a newly isolated Pseudomonas strain. Appl Biochem Biotechnol. 2015 May;176(2):636-44. doi: 10.1007/s12010-015-1601-7. Epub 2015 Apr 9. PMID: 25855238.