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MedKoo Cat#: 555743 | Name: LSL-60101

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LSL60101 is a selective ligand for imidazoline I2 receptors, on glial fibrillary acidic protein concentration.

Chemical Structure

LSL-60101
LSL-60101
CAS#150985-54-9

Theoretical Analysis

MedKoo Cat#: 555743

Name: LSL-60101

CAS#: 150985-54-9

Chemical Formula: C11H8N2O

Exact Mass: 184.0637

Molecular Weight: 184.20

Elemental Analysis: C, 71.73; H, 4.38; N, 15.21; O, 8.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LSL60101; LSL-60101; LSL 60101;
IUPAC/Chemical Name
2-(2-Benzofuranyl)-1H-imidazole
InChi Key
VBFQIUOSXHUWCT-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H8N2O/c1-2-4-9-8(3-1)7-10(14-9)11-12-5-6-13-11/h1-7H,(H,12,13)
SMILES Code
C1(C2=CC3=CC=CC=C3O2)=NC=CN1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 184.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Garau C, Miralles A, García-Sevilla JA. Chronic treatment with selective I2-imidazoline receptor ligands decreases the content of pro-apoptotic markers in rat brain. J Psychopharmacol. 2013 Feb;27(2):123-34. doi: 10.1177/0269881112450785. Epub 2012 Jun 20. PMID: 22719017. 2: Miralles A, Esteban S, Sastre-Coll A, Moranta D, Asensio VJ, García-Sevilla JA. High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain. Eur J Pharmacol. 2005 Aug 22;518(2-3):234-42. doi: 10.1016/j.ejphar.2005.06.023. PMID: 16061219. 3: Casanovas A, Olmos G, Ribera J, Boronat MA, Esquerda JE, García-Sevilla JA. Induction of reactive astrocytosis and prevention of motoneuron cell death by the I(2)-imidazoline receptor ligand LSL 60101. Br J Pharmacol. 2000 Aug;130(8):1767-76. doi: 10.1038/sj.bjp.0703485. PMID: 10952664; PMCID: PMC1572252. 4: Sánchez-Blázquez P, Boronat MA, Olmos G, García-Sevilla JA, Garzón J. Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol. 2000 May;130(1):146-52. doi: 10.1038/sj.bjp.0703294. PMID: 10781010; PMCID: PMC1572044. 5: Olmos G, DeGregorio-Rocasolano N, Paz Regalado M, Gasull T, Assumpció Boronat M, Trullas R, Villarroel A, Lerma J, García-Sevilla JA. Protection by imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor. Br J Pharmacol. 1999 Jul;127(6):1317-26. doi: 10.1038/sj.bjp.0702679. PMID: 10455281; PMCID: PMC1760666. 6: Escribá PV, Ozaita A, García-Sevilla JA. Pharmacologic characterization of imidazoline receptor proteins identified by immunologic techniques and other methods. Ann N Y Acad Sci. 1999 Jun 21;881:8-25. doi: 10.1111/j.1749-6632.1999.tb09336.x. PMID: 10415892. 7: Boronat MA, Olmos G, García-Sevilla JA. Attenuation of tolerance to opioid- induced antinociception and protection against morphine-induced decrease of neurofilament proteins by idazoxan and other I2-imidazoline ligands. Br J Pharmacol. 1998 Sep;125(1):175-85. doi: 10.1038/sj.bjp.0702031. PMID: 9776358; PMCID: PMC1565592. 8: Ozaita A, Olmos G, Boronat MA, Lizcano JM, Unzeta M, García-Sevilla JA. Inhibition of monoamine oxidase A and B activities by imidazol(ine)/guanidine drugs, nature of the interaction and distinction from I2-imidazoline receptors in rat liver. Br J Pharmacol. 1997 Jul;121(5):901-12. doi: 10.1038/sj.bjp.0701214. PMID: 9222546; PMCID: PMC1564771. 9: Hosseini AR, King PR, Louis WJ, Gundlach AL. [3H]2-(2-Benzofuranyl)-2-imidazoline, a highly selective radioligand for I2-imidazoline receptor binding sites. Studies in rabbit kidney membranes. Naunyn Schmiedebergs Arch Pharmacol. 1997 Jan;355(1):131-8. doi: 10.1007/pl00004911. PMID: 9007853. 10: Escribá PV, Alemany R, Sastre M, Olmos G, Ozaita A, García-Sevilla JA. Pharmacological modulation of immunoreactive imidazoline receptor proteins in rat brain: relationship with non-adrenoceptor [3H]-idazoxan binding sites. Br J Pharmacol. 1996 Aug;118(8):2029-36. doi: 10.1111/j.1476-5381.1996.tb15640.x. PMID: 8864539; PMCID: PMC1909863. 11: Menargues A, Cedó M, Artiga O, Obach R, García-Sevilla JA. Effects of the I2-imidazoline receptor ligand LSL 60101 on various models of anorexia in rats. Ann N Y Acad Sci. 1995 Jul 12;763:494-6. doi: 10.1111/j.1749-6632.1995.tb32439.x. PMID: 7677363. 12: García-Sevilla JA, Alemany R, Olmos G, Menargues A, Obach R. Chronic imidazoline drug treatment increases the immunoreactivity of glial fibrillary acidic protein in rat brain. LSL 60101 as a novel and selective ligand for I2-imidazoline receptors. Ann N Y Acad Sci. 1995 Jul 12;763:486-9. doi: 10.1111/j.1749-6632.1995.tb32437.x. PMID: 7677361. 13: Alemany R, Olmos G, Escribá PV, Menargues A, Obach R, García-Sevilla JA. LSL 60101, a selective ligand for imidazoline I2 receptors, on glial fibrillary acidic protein concentration. Eur J Pharmacol. 1995 Jul 4;280(2):205-10. doi: 10.1016/0014-2999(95)00214-6. PMID: 7589187.