MedKoo Cat#: 555734 | Name: GS-4361
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GS-4361 is a potent and selective IDO1 inhibitor with an EC50 of 17 nM, GS-4361 was first reported in patent WO2019040102A.

Chemical Structure

GS-4361
GS-4361
CAS#2291164-02-6

Theoretical Analysis

MedKoo Cat#: 555734

Name: GS-4361

CAS#: 2291164-02-6

Chemical Formula: C26H17F3N4O

Exact Mass: 458.1354

Molecular Weight: 458.44

Elemental Analysis: C, 68.12; H, 3.74; F, 12.43; N, 12.22; O, 3.49

Price and Availability

Size Price Availability Quantity
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 1,950.00 2 Weeks
500mg USD 2,850.00 2 Weeks
1g USD 4,250.00 2 Weeks
2g USD 7,250.00 2 Weeks
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Related CAS #
No Data
Synonym
GS-4361; GS 4361; GS4361; IDO-IN-13
IUPAC/Chemical Name
5-[3-(2,3-Difluorophenyl)imidazo[1,5-a]pyridin-8-yl]-N-(4-fluorophenyl)-2-methyl-3-pyridinecarboxamide
InChi Key
MBXPCHYYQRPOOA-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H17F3N4O/c1-15-21(26(34)32-18-9-7-17(27)8-10-18)12-16(13-30-15)19-5-3-11-33-23(19)14-31-25(33)20-4-2-6-22(28)24(20)29/h2-14H,1H3,(H,32,34)
SMILES Code
O=C(C1=CC(C2=CC=CN3C2=CN=C3C4=CC=CC(F)=C4F)=CN=C1C)NC5=CC=C(F)C=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an EC50 of 17 nM.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 458.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
[1]. Mark J. BARTLETT, et al. Therapeutic heterocyclic compounds. WO2019040102A1. https://patents.google.com/patent/WO2019040102A1