Synonym
STING inhibitor C-170; STING inhibitor-C-170; STING inhibitor C 170
IUPAC/Chemical Name
N-(4-Butylphenyl)-5-nitrofuran-2-carboxamide
InChi Key
QMVOHFICEFYHMK-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H16N2O4/c1-2-3-4-11-5-7-12(8-6-11)16-15(18)13-9-10-14(21-13)17(19)20/h5-10H,2-4H2,1H3,(H,16,18)
SMILES Code
O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(CCCC)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
288.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Zang R, Xue L, Zhang M, Peng X, Li X, Du K, Shi C, Liu Y, Lin Y, Han W, Yu R, Wang Q, Yang J, Wang X, Jiang T. Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist. Eur J Med Chem. 2023 Mar 15;250:115184. doi: 10.1016/j.ejmech.2023.115184. Epub 2023 Feb 4. PMID: 36758305.
Liu J, Yuan L, Ruan Y, Deng B, Yang Z, Ren Y, Li L, Liu T, Zhao H, Mai R, Chen J. Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy. J Med Chem. 2022 May 12;65(9):6593-6611. doi: 10.1021/acs.jmedchem.1c01948. Epub 2022 Apr 22. PMID: 35452223.
